Controlling scissors during DNA repair of UV light-induced damage.

IF 6.1 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2026-07-14 DOI:10.1083/jcb.202606004

Patricia L Opresko,Orlando D Schärer

引用次数: 0

Abstract

Nucleotide excision repair is essential for genome stability; however, enzymatic scissors that remove damage must be tightly regulated to prevent erroneous DNA cleavage. In this issue, Muniesa-Vargas et al. (https://doi.org/10.1083/jcb.202602121) used live-cell imaging to uncover how cutting DNA by XPG endonuclease is controlled during repair.

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在紫外线诱导的DNA损伤修复过程中控制剪刀。

核苷酸切除修复对基因组稳定至关重要；然而，清除损伤的酶剪刀必须严格调节，以防止错误的DNA切割。在这一期中，Muniesa-Vargas等人（https://doi.org/10.1083/jcb.202602121）利用活细胞成像揭示了在修复过程中如何控制XPG内切酶切割DNA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.