Longitudinal associations of chronic pain and sleep quality with frailty progression in community-dwelling older adults

IF 4.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Aging Clinical and Experimental Research Pub Date : 2026-07-09 Epub Date: 2026-10-02 DOI:10.1007/s40520-026-03439-8

Daijo Shiratsuchi, Hyuma Makizako, Shoma Akaida, Mana Tateishi, Yuto Kiuchi, Ryota Kuratsu, Takuro Kubozono, Toshihiro Takenaka, So Kuwahata, Mitsuru Ohishi

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引用次数: 0

Abstract

Background

Chronic pain is associated with frailty in older adults; however, the mechanisms underlying this relationship are not fully understood.

Aims

To examine whether sleep quality is involved in the longitudinal association between chronic pain and frailty progression in community-dwelling older adults.

Methods

This longitudinal study included 363 community-dwelling adults aged ≥ 65 years who participated in the 2018 and 2019 waves of the Tarumizu Study in Japan. Chronic pain was defined as self-reported lower back and/or knee pain lasting for at least 2 months. Sleep quality was assessed using a single-item questionnaire and categorized as good, medium, or poor. Frailty was assessed using the Kihon Checklist, and progression was defined as an increase ≥ 2 points over 1 year. Logistic regression and mediation analyses were conducted.

Results

Frailty progression was observed in 27.3% of participants. Chronic pain was significantly associated with frailty progression (odds ratio [OR]: 1.79; 95% confidence interval [CI]: 1.08–2.97), although this association was attenuated after adjustment for sleep quality. Poor sleep quality was independently associated with frailty progression (OR: 2.02; 95% CI: 1.04–3.91). Mediation analysis showed a significant indirect effect of chronic pain on frailty progression through sleep quality (β = 0.08; 95% CI: 0.001–0.20).

Discussion

Poor sleep quality may represent one potential pathway underlying the association between chronic pain and frailty progression in community-dwelling older adults.

Conclusions

Integrated assessment of pain and sleep problems may help identify older adults at greater risk of frailty progression.

查看原文本刊更多论文

社区居住老年人慢性疼痛和睡眠质量与衰弱进展的纵向关联。

背景：慢性疼痛与老年人虚弱有关；然而，这种关系背后的机制尚不完全清楚。目的：研究在社区居住的老年人中，睡眠质量是否与慢性疼痛和虚弱进展之间的纵向关联有关。方法：本纵向研究包括363名≥65岁的社区居民，他们参加了2018年和2019年日本Tarumizu研究。慢性疼痛定义为自我报告的腰部和/或膝盖疼痛持续至少2个月。睡眠质量通过单项调查问卷进行评估，分为好、中、差三个等级。使用Kihon检查表对虚弱进行评估，并将进展定义为1年内增加≥2分。进行了Logistic回归和中介分析。结果：27.3%的参与者出现虚弱进展。慢性疼痛与衰弱进展显著相关（优势比[OR]: 1.79； 95%可信区间[CI]: 1.08-2.97），尽管在调整睡眠质量后这种关联减弱。睡眠质量差与虚弱进展独立相关（OR: 2.02; 95% CI: 1.04-3.91）。中介分析显示慢性疼痛通过睡眠质量对衰弱进展有显著的间接影响（β = 0.08; 95% CI: 0.001-0.20）。讨论：在社区居住的老年人中，睡眠质量差可能是慢性疼痛和虚弱进展之间联系的一个潜在途径。结论：对疼痛和睡眠问题的综合评估可能有助于识别有更大衰弱进展风险的老年人。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Aging Clinical and Experimental Research 医学-老年医学

CiteScore

7.90

自引率

5.00%

发文量

283

审稿时长

1 months

期刊介绍： Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.