Improved Synthesis of a Key Intermediate of Onapristone

IF 3.3 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2026-07-17 Epub Date: 2026-07-08 DOI:10.1021/acs.oprd.6c00013

Fei Lv, Qihua Zhao, Jiaoyang Feng, Ziyang Jia, Erin Zebrowski, Anjiang Yang*, Boyu Zhong* and Tony Yantao Zhang*,

引用次数: 0

Abstract

We report a novel, single-step, and scalable synthesis of ONA-3, a key advanced intermediate of onapristone. The process strategically employs an inexpensive starting material ONA-2 that also serves as an advanced intermediate in mifepristone production, ensuring a steady material supply on a metric ton scale. Compared to existing methods, this streamlined approach dramatically reduces the estimated cost of goods (COGS) to 32% and the manufacturing cycle time to 20%. Ultimately, this concise and highly cost-effective manufacturing process provides a strengthening solution to the supply chain challenges of onapristone.

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奥那匹司酮关键中间体的改进合成

我们报道了一种新的、单步的、可扩展的ONA-3合成方法，onapristone的一个关键的高级中间体。该工艺战略性地采用了一种廉价的起始材料ONA-2，该材料也可作为米非司酮生产的高级中间体，确保以公吨规模稳定的材料供应。与现有的方法相比，这种简化的方法大大降低了估计的货物成本（COGS）到32%，制造周期时间到20%。最终，这种简洁和高成本效益的制造工艺为奥纳匹司通的供应链挑战提供了一个加强的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.