Organic planar π-conjugated anions enable structural design of anion-π+ NIR-II phototheranostic agents.

IF 18.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications Pub Date : 2026-07-08 DOI:10.1038/s41467-026-75247-7

Ying Zhang,Mingyang Han,Guoyu Jiang,Lingxiu Liu,Chunbin Li,Lina Feng,Jianye Gong,Jianguo Wang,Ben Zhong Tang

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引用次数: 0

Abstract

Anion-π+ phototheranostic agents (PTAs) have attracted considerable interest for their exceptional luminescence and reactive oxygen species (ROS). However, current development is constrained by limited structural diversity and lack of second near-infrared (NIR-II) emission and photothermal performance, with the role of organic π-conjugated anions remaining unexplored. Here, we propose an organic π-conjugated anion-exchange strategy to construct advanced NIR-II PTAs. DTPAP-2B (with Br-) and DTPAP-2P (with pentacyanocyclopentadiene anion ((CCN)5-)), were synthesized. Upon nanoformulation, DTPAP-2P NPs exhibit pronounced absorption redshift, intense NIR-II emission, a large Stokes shift (340 nm), superior ROS generation, and high photothermal conversion efficiency (72%) compared to DTPAP-2B NPs. Single-crystal and theoretical analyses reveal that the planar (CCN)5- anion enhances dual anion-π+ interactions, promoting intramolecular charge transfer while suppressing intermolecular π-π stacking. This enables high-resolution NIR-II angiography and effective NIR-II imaging-guided synergistic photodynamic/photothermal therapy in female mice model. This work establishes organic π-conjugated anion exchange as a powerful strategy for developing robust NIR-II PTAs.

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有机平面π共轭阴离子使得阴离子-π+ NIR-II光治疗剂的结构设计成为可能。

阴离子-π+光疗剂（PTAs）因其特殊的发光和活性氧（ROS）而引起了人们的广泛关注。然而，目前的发展受到结构多样性有限、二次近红外（NIR-II）发射和光热性能不足的制约，有机π共轭阴离子的作用尚未得到充分的探索。本文提出了一种有机π共轭阴离子交换策略来构建先进的NIR-II PTAs。合成了DTPAP-2B（含Br-）和DTPAP-2P（含五氰环戊二烯阴离子（(CCN)5-））。与DTPAP-2B NPs相比，DTPAP-2P NPs表现出明显的吸收红移、强烈的NIR-II发射、大的Stokes位移（340 nm）、优越的ROS生成和高光热转换效率（72%）。单晶和理论分析表明，平面（CCN）5-阴离子增强双阴离子-π+相互作用，促进分子内电荷转移，抑制分子间π-π堆积。这使得高分辨率NIR-II血管造影和有效的NIR-II成像引导下的雌性小鼠模型协同光动力/光热治疗成为可能。本研究确立了有机π共轭阴离子交换是制备强效NIR-II pta的有效策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.