{"title":"[Anabolic treatment in geriatric patients with osteoporosis].","authors":"Judith Haschka","doi":"10.1007/s00391-026-02605-x","DOIUrl":null,"url":null,"abstract":"<p><p>Osteoporotic fractures are a major cause of morbidity, functional decline, and mortality in older adults. Despite effective treatment options, a substantial treatment gap persists in primary and secondary fracture prevention. Osteoanabolic agents stimulate bone formation and lead to a rapid improvement in bone mineral density and bone microarchitecture. Clinical trials demonstrate superiority over antiresorptive therapies in patients at very high or imminent risk of fracture; however, treatment in geriatric populations requires a differentiated balancing of the benefit-risk ratio with careful consideration of comorbidities, administration feasibility and cardiovascular safety. This CME article provides a clinically oriented overview of mechanisms of action, efficacy, safety and practical decision strategies for osteoanabolic treatment in older individuals.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":"435-442"},"PeriodicalIF":1.1000,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift Fur Gerontologie Und Geriatrie","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00391-026-02605-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/7/8 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Osteoporotic fractures are a major cause of morbidity, functional decline, and mortality in older adults. Despite effective treatment options, a substantial treatment gap persists in primary and secondary fracture prevention. Osteoanabolic agents stimulate bone formation and lead to a rapid improvement in bone mineral density and bone microarchitecture. Clinical trials demonstrate superiority over antiresorptive therapies in patients at very high or imminent risk of fracture; however, treatment in geriatric populations requires a differentiated balancing of the benefit-risk ratio with careful consideration of comorbidities, administration feasibility and cardiovascular safety. This CME article provides a clinically oriented overview of mechanisms of action, efficacy, safety and practical decision strategies for osteoanabolic treatment in older individuals.
期刊介绍：
The fact that more and more people are becoming older and are having a significant influence on our society is due to intensive geriatric research and geriatric medicine in the past and present. The Zeitschrift für Gerontologie und Geriatrie has contributed to this area for many years by informing a broad spectrum of interested readers about various developments in gerontology research. Special issues focus on all questions concerning gerontology, biology and basic research of aging, geriatric research, psychology and sociology as well as practical aspects of geriatric care.
Target group: Geriatricians, social gerontologists, geriatric psychologists, geriatric psychiatrists, nurses/caregivers, nurse researchers, biogerontologists in geriatric wards/clinics, gerontological institutes, and institutions of teaching and further or continuing education.
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