Serum levels of SIRT3 in elderly patients undergoing general anesthesia and its relationship with postoperative delirium.

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2026-07-07 eCollection Date: 2026-01-01 DOI:10.1515/med-2025-1359

Linfeng Li, Huai Zhang, Rong Qian, HuiJuan Wang, Min Zhang, Lu Tang, Min Liao

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引用次数: 0

Abstract

Objectives: To investigate whether serum SIRT3 levels can predict postoperative delirium (POD) in elderly patients undergoing general anesthesia.

Methods: A prospective observational study was conducted on 118 elderly patients who underwent general anesthesia from January 2021 to December 2023. POD was assessed using the Confusion Assessment Method (CAM) within 72 h post-surgery. Serum SIRT3, IL-6, IL-1β, IL-17, and CRP levels were measured by ELISA. Clinical data including surgical time, anesthesia time, and blood loss were recorded. Statistical analysis was performed using SPSS 25.0 (p<0.05 considered significant).

Results: Compared to non-POD patients, those with POD had longer surgery and anesthesia durations, lower hemoglobin and albumin levels, significantly lower serum SIRT3, and higher IL-6, IL-1β, and IL-17 levels. Serum SIRT3 was inversely correlated with IL-1β and IL-17. ROC analysis suggested SIRT3 as a potential predictive biomarker for POD. Logistic regression identified low SIRT3, low albumin, and elevated IL-1β and IL-17 as risk factors.

Conclusions: Serum SIRT3 is significantly reduced in elderly POD patients and may serve as a predictive biomarker and potential therapeutic target for POD.

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老年全麻患者血清SIRT3水平及其与术后谵妄的关系。

目的：探讨血清SIRT3水平对老年全麻患者术后谵妄（POD）的预测作用。方法：对2021年1月至2023年12月行全身麻醉的118例老年患者进行前瞻性观察研究。术后72 h内使用混淆评估法（CAM）对POD进行评估。ELISA法检测血清SIRT3、IL-6、IL-1β、IL-17、CRP水平。记录手术时间、麻醉时间、出血量等临床资料。结果：与非POD患者相比，POD患者手术和麻醉时间更长，血红蛋白和白蛋白水平较低，血清SIRT3明显降低，IL-6、IL-1β和IL-17水平较高。血清SIRT3与IL-1β、IL-17呈负相关。ROC分析提示SIRT3是POD的潜在预测生物标志物。Logistic回归发现SIRT3水平低、白蛋白水平低、IL-1β和IL-17水平升高是危险因素。结论：老年POD患者血清SIRT3明显降低，可能作为POD的预测性生物标志物和潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.