Body Mass Index Trajectories Among Patients with Drug-Susceptible and Drug-Resistant Tuberculosis in Northwest Ethiopia.

IF 5.6 3区医学 Q1 INFECTIOUS DISEASES

Infectious Diseases and Therapy Pub Date : 2026-09-01 Epub Date: 2026-07-07 DOI:10.1007/s40121-026-01404-6

Fasil Wagnew, Kefyalew Addis Alene, Matthew Kelly, Darren Gray

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引用次数: 0

Abstract

Introduction: Understanding predictors of body mass index (BMI) trajectories in patients with drug-susceptible tuberculosis (DS-TB) and drug-resistant TB (DR-TB) is crucial for optimizing treatment strategies. This study examined BMI trajectories and predictors among patients with DS-TB and DR-TB in northwest Ethiopia.

Methods: A retrospective cohort study was conducted using clinical data from patients attending TB clinics at four public hospitals in Northwest Ethiopia. We modelled BMI trajectories after TB treatment initiation using linear mixed models, with adjustments for potential confounders.

Results: A total of 988 patients were included in the analysis, comprising 569 with DS-TB and 419 with DR-TB. In the DS-TB cohort, male sex was associated with higher mean BMI (β = 0.39; 95% CI: 0.12-0.65), while baseline underweight status (β = -4.07; 95% CI: -4.33, -3.82) and baseline anaemia (β = -0.27; 95% CI: -0.53, -0.02) were associated with lower mean BMI across follow-up. In the DR-TB cohort, men had a higher mean BMI than women across the follow-up (β = 0.64; 95% CI: 0.16, 1.12). Although participants who were underweight at baseline (β = -3.62; 95% CI -4.06 to -3.18) or anaemic (β = -0.54; 95% CI: -0.98, -0.10) had a lower mean BMI across follow-up, they gained BMI more rapidly over time (time*underweight β = 0.04, 95% CI: 0.01, 0.07; time*anaemia β = 0.05, 95% CI: 0.01, 0.08).

Conclusion: Early nutritional assessment and tailored nutritional support should be strengthened as part of routine TB care.

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埃塞俄比亚西北部药敏和耐药结核病患者的体重指数轨迹

前言：了解药物敏感结核病（DS-TB）和耐药结核病（DR-TB）患者的体重指数（BMI）轨迹预测因子对于优化治疗策略至关重要。本研究调查了埃塞俄比亚西北部DS-TB和DR-TB患者的BMI轨迹和预测因素。方法：对埃塞俄比亚西北部四家公立医院结核病门诊患者的临床资料进行回顾性队列研究。我们使用线性混合模型对结核病治疗开始后的BMI轨迹进行建模，并对潜在的混杂因素进行了调整。结果：共纳入988例患者，其中DS-TB 569例，DR-TB 419例。在DS-TB队列中，男性与较高的平均BMI相关（β = 0.39; 95% CI: 0.12-0.65），而基线体重不足状态（β = -4.07; 95% CI: -4.33, -3.82）和基线贫血（β = -0.27; 95% CI: -0.53, -0.02）与随访期间较低的平均BMI相关。在耐药结核病队列中，男性在随访期间的平均BMI高于女性（β = 0.64; 95% CI: 0.16, 1.12）。虽然基线体重不足（β = -3.62; 95% CI: -4.06至-3.18）或贫血（β = -0.54; 95% CI: -0.98, -0.10）的参与者在随访期间的平均BMI较低，但随着时间的推移，他们的BMI增加得更快（时间*体重不足β = 0.04, 95% CI: 0.01, 0.07；时间*贫血β = 0.05, 95% CI: 0.01, 0.08）。结论：应加强早期营养评估和量身定制的营养支持，作为结核病常规治疗的一部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Diseases and Therapy Medicine-Microbiology (medical)

CiteScore

8.60

自引率

1.90%

发文量

136

审稿时长

6 weeks

期刊介绍： Infectious Diseases and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of infectious disease therapies and interventions, including vaccines and devices. Studies relating to diagnostic products and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to, bacterial and fungal infections, viral infections (including HIV/AIDS and hepatitis), parasitological diseases, tuberculosis and other mycobacterial diseases, vaccinations and other interventions, and drug-resistance, chronic infections, epidemiology and tropical, emergent, pediatric, dermal and sexually-transmitted diseases.