Significance of leptin, Galectin-1 and Galectin-3 in tumor lymphangiogenesis.

IF 1.2 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Acta gastro-enterologica Belgica Pub Date : 2026-04-01 DOI:10.51821/89.2.14594

S M Petrovic, B Simovic Markovic, I Jovanovic, A Jevtovic, J Pantic, G D Radosavljevic

{"title":"Significance of leptin, Galectin-1 and Galectin-3 in tumor lymphangiogenesis.","authors":"S M Petrovic, B Simovic Markovic, I Jovanovic, A Jevtovic, J Pantic, G D Radosavljevic","doi":"10.51821/89.2.14594","DOIUrl":null,"url":null,"abstract":"Background and study aims: Leptin, Galectin-1 and Galectin-3 are essential players in tumorigenesis, angiogenesis, and metastasis, but their lymphangiogenic role is unclear. Here, the associations of leptin, Galectin-1 and Galectin-3 with markers of lymphangiogenesis were evaluated in colorectal cancer (CRC).Patients and methods: A total of 120 patients with CRC were included in the study. The expressions of leptin, Galectin-1, Galectin-3, and vascular endothelial growth factor- C (VEGF-C) were analyzed in CRC tissue and compared with lymphatic vessel density (LVD). Also, the concentrations of Galectin-1 and Galectin-3 were determined in the sera of CRC patients (n=38).Results: LVD positively correlated with the intensity of leptin or Galectin-1 expression (as defined by intensity score, IS) in tissues. Although there was no significant association between tissue expression of Galectin-3 and LVD, serum Galectin-3 concentrations were markedly decreased in patients with high LVD. The positive correlation was observed between intensity of VEGF-C and leptin expressions. No significant relationship was found between VEGF-C and Galectin-1 expression, while the intensity of VEGF-C expression positively correlated with Galectin-3 expression in tumor tissue. Further, high leptin expression, determined by a total score (sum of percentage score (PS) and IS) > 4, was related to regional lymph node metastasis and TNM stages, indicating a more aggressive CRC phenotype.Conclusions: The results suggest that leptin and Galectin-1 are involved in the formation of new lymphatic vessels in tumor, either dependently or independently of VEGF-C. It seems that high leptin expression reflects regional metastases and progression of CRC.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"89 2","pages":"285-294"},"PeriodicalIF":1.2000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta gastro-enterologica Belgica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.51821/89.2.14594","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background and study aims: Leptin, Galectin-1 and Galectin-3 are essential players in tumorigenesis, angiogenesis, and metastasis, but their lymphangiogenic role is unclear. Here, the associations of leptin, Galectin-1 and Galectin-3 with markers of lymphangiogenesis were evaluated in colorectal cancer (CRC).

Patients and methods: A total of 120 patients with CRC were included in the study. The expressions of leptin, Galectin-1, Galectin-3, and vascular endothelial growth factor- C (VEGF-C) were analyzed in CRC tissue and compared with lymphatic vessel density (LVD). Also, the concentrations of Galectin-1 and Galectin-3 were determined in the sera of CRC patients (n=38).

Results: LVD positively correlated with the intensity of leptin or Galectin-1 expression (as defined by intensity score, IS) in tissues. Although there was no significant association between tissue expression of Galectin-3 and LVD, serum Galectin-3 concentrations were markedly decreased in patients with high LVD. The positive correlation was observed between intensity of VEGF-C and leptin expressions. No significant relationship was found between VEGF-C and Galectin-1 expression, while the intensity of VEGF-C expression positively correlated with Galectin-3 expression in tumor tissue. Further, high leptin expression, determined by a total score (sum of percentage score (PS) and IS) > 4, was related to regional lymph node metastasis and TNM stages, indicating a more aggressive CRC phenotype.

Conclusions: The results suggest that leptin and Galectin-1 are involved in the formation of new lymphatic vessels in tumor, either dependently or independently of VEGF-C. It seems that high leptin expression reflects regional metastases and progression of CRC.

查看原文本刊更多论文

瘦素、半凝集素-1和半凝集素-3在肿瘤淋巴管生成中的意义。

背景与研究目的：瘦素、半乳糖凝集素-1和半乳糖凝集素-3在肿瘤发生、血管生成和转移中发挥着重要作用，但其在淋巴管生成中的作用尚不清楚。本研究评估了结直肠癌（CRC）中瘦素、半乳糖凝集素-1和半乳糖凝集素-3与淋巴管生成标志物的关系。患者和方法：共纳入120例结直肠癌患者。分析结直肠癌组织中瘦素、半乳糖凝集素-1、半乳糖凝集素-3和血管内皮生长因子-C （VEGF-C）的表达，并与淋巴管密度（LVD）进行比较。同时测定38例结直肠癌患者血清中Galectin-1和Galectin-3的浓度。结果：LVD与组织中瘦素或半乳糖凝集素-1表达强度（以强度评分IS定义）呈正相关。尽管组织中半乳糖凝集素-3的表达与LVD之间无显著相关性，但高LVD患者血清半乳糖凝集素-3浓度明显降低。VEGF-C强度与瘦素表达呈正相关。VEGF-C与半乳糖凝集素-1表达无显著相关性，而VEGF-C表达强度与肿瘤组织半乳糖凝集素-3表达呈正相关。此外，由总分（百分比分数（PS）和IS的总和）bbbb4确定的高瘦素表达与区域淋巴结转移和TNM分期有关，表明CRC表型更具侵袭性。结论：结果提示瘦素和半乳糖凝集素-1参与肿瘤新淋巴管的形成，依赖或独立于VEGF-C。高瘦素表达反映了结直肠癌的区域转移和进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta gastro-enterologica Belgica Medicine-Gastroenterology

CiteScore

2.30

自引率

20.00%

发文量

期刊介绍： The Journal Acta Gastro-Enterologica Belgica principally publishes peer-reviewed original manuscripts, reviews, letters to editors, book reviews and guidelines in the field of clinical Gastroenterology and Hepatology, including digestive oncology, digestive pathology, as well as nutrition. Pure animal or in vitro work will not be considered for publication in the Journal. Translational research papers (including sections of animal or in vitro work) are considered by the Journal if they have a clear relationship to or relevance for clinical hepato-gastroenterology (screening, disease mechanisms and/or new therapies). Case reports and clinical images will be accepted if they represent an important contribution to the description, the pathogenesis or the treatment of a specific gastroenterology or liver problem. The language of the Journal is English. Papers from any country will be considered for publication. Manuscripts submitted to the Journal should not have been published previously (in English or any other language), nor should they be under consideration for publication elsewhere. Unsolicited papers are peer-reviewed before it is decided whether they should be accepted, rejected, or returned for revision. Manuscripts that do not meet the presentation criteria (as indicated below) will be returned to the authors. Papers that go too far beyond the scope of the journal will be also returned to the authors by the editorial board generally within 2 weeks. The Journal reserves the right to edit the language of papers accepted for publication for clarity and correctness, and to make formal changes to ensure compliance with AGEB’s style. Authors have the opportunity to review such changes in the proofs.