Dupilumab-Associated Erythema Multiforme-Like Eruption With Lichenoid Histology in a Paediatric Patient: A Case Report.

Abstract

Dupilumab-associated erythema multiforme and lichenoid eruptions have been previously reported as rare dermatological adverse events. We present an atypical paediatric case of a dupilumab-associated erythema multiforme-like eruption in a 5-year-old male eczema patient, who developed erythematous targetoid papules and plaques over the upper and lower limbs, with a biopsy suggestive of a lichenoid interface reaction. Dupilumab was discontinued, and the side effect was managed with topical corticosteroids, leading to resolution of the lesions with mild residual post-inflammatory skin hyperpigmentation.