The gut microbiota-bone marrow axis: an emerging role in chemotherapy-induced myelosuppression.

IF 11.4 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

npj Biofilms and Microbiomes Pub Date : 2026-07-06 DOI:10.1038/s41522-026-01080-x

Li Gong, Yeqi Wang, Yongsheng Li, Junli Huang

引用次数: 0

Abstract

Accumulating evidence indicates that gut microbiota extensively modulates the toxicity of chemotherapeutics. However, the role of microbiota in chemotherapy-induced myelosuppression (CIM) remains poorly characterized. This review synthesizes the pivotal role of gut microbiota in regulating hematopoiesis, summarizes recent findings on the links between gut microbiota and CIM, and discusses emerging strategies for alleviating CIM through microbiota modulation. Our analysis pinpoints key gaps and novel insights for targeted CIM therapies.

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肠道微生物群-骨髓轴：在化疗诱导的骨髓抑制中的新作用。

越来越多的证据表明，肠道微生物群广泛调节化疗药物的毒性。然而，微生物群在化疗诱导的骨髓抑制（CIM）中的作用仍然不清楚。本文综述了肠道微生物群在调节造血中的关键作用，总结了肠道微生物群与CIM之间联系的最新发现，并讨论了通过微生物群调节缓解CIM的新策略。我们的分析指出了靶向CIM治疗的关键差距和新见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology

CiteScore

12.10

自引率

3.30%

发文量

审稿时长

9 weeks

期刊介绍： npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.