Maria Andréa da Silva, Valéria Regina de Souza Moraes, Raphael Amancio de Jesus, José Michael da Silva, Heloyza Stefanny de Jesus Correa, Lorena Cristina Santos Araújo
{"title":"Cosmetic Products Containing Rutin: A Systematic Review of Patents from 2014 to 2024.","authors":"Maria Andréa da Silva, Valéria Regina de Souza Moraes, Raphael Amancio de Jesus, José Michael da Silva, Heloyza Stefanny de Jesus Correa, Lorena Cristina Santos Araújo","doi":"10.2174/0115680266414480251024071716","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Rutin is a natural flavonoid with several validated benefits for cosmetic use and has been increasingly incorporated into cosmetic and dermocosmetic formulas, especially for its antioxidant potential.</p><p><strong>Methods: </strong>A search for patents on the use of rutin in cosmetics was conducted at the European Patent Office (EPO), the World Intellectual Property Organization (WIPO), and the National Institute of Intellectual Property (INPI-Brazil). The search strategy used (i) \"rutin\" AND (ii) \"Cosmetics\" OR \"Skin Cream\" OR \"Cosmeceuticals\" AND \"A61K8\" OR \"C07H17\".</p><p><strong>Results: </strong>A total of 38 patents were selected, 27 of which emphasized the anti-wrinkle and/or antiaging, sunscreen, and antioxidant effects of their formulations. Fifteen patents reported the botanical origin of the rutin used, highlighting the growing interest in developing new cosmetics from different plant sources.</p><p><strong>Discussion: </strong>It has been observed that cosmetic compositions containing rutin can combine natural and synthetic active ingredients to achieve synergistic effects. The use of pharmaceutical technologies and structural modifications to the rutin molecule has been reported, including polyglycosylated rutin, troxerutin, and rutin hydroxycinnamate, to improve the molecule's physicochemical properties.</p><p><strong>Conclusion: </strong>Structural modifications to rutin can optimize its effects, and the main technologies described in the patents, such as microencapsulation and nanoliposomes, aim to improve the efficacy of the active ingredients, facilitating their application in cosmetic formulations in both cases. Considering this, we emphasize the potential of local flora as promising sources for cosmetic development and research.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266414480251024071716","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Rutin is a natural flavonoid with several validated benefits for cosmetic use and has been increasingly incorporated into cosmetic and dermocosmetic formulas, especially for its antioxidant potential.
Methods: A search for patents on the use of rutin in cosmetics was conducted at the European Patent Office (EPO), the World Intellectual Property Organization (WIPO), and the National Institute of Intellectual Property (INPI-Brazil). The search strategy used (i) "rutin" AND (ii) "Cosmetics" OR "Skin Cream" OR "Cosmeceuticals" AND "A61K8" OR "C07H17".
Results: A total of 38 patents were selected, 27 of which emphasized the anti-wrinkle and/or antiaging, sunscreen, and antioxidant effects of their formulations. Fifteen patents reported the botanical origin of the rutin used, highlighting the growing interest in developing new cosmetics from different plant sources.
Discussion: It has been observed that cosmetic compositions containing rutin can combine natural and synthetic active ingredients to achieve synergistic effects. The use of pharmaceutical technologies and structural modifications to the rutin molecule has been reported, including polyglycosylated rutin, troxerutin, and rutin hydroxycinnamate, to improve the molecule's physicochemical properties.
Conclusion: Structural modifications to rutin can optimize its effects, and the main technologies described in the patents, such as microencapsulation and nanoliposomes, aim to improve the efficacy of the active ingredients, facilitating their application in cosmetic formulations in both cases. Considering this, we emphasize the potential of local flora as promising sources for cosmetic development and research.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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