Breast cancer and coronary artery disease: insights from a national inpatient sample analysis.

IF 1.1 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Future cardiology Pub Date : 2026-07-01 Epub Date: 2026-07-06 DOI:10.1080/14796678.2026.2692606

Omar Obeidat, Moh'd Daise, Qusai Alqudah, Mohammad Tarawneh, Hashim Al-Ani, Laith Alhuneafat, Ali Obeidat, Mohamed F Ismail, Abedallah Obeidat, Saeed Abughazaleh, Maria Obeidat, Jowan Al-Nusair, Ann Tong

{"title":"Breast cancer and coronary artery disease: insights from a national inpatient sample analysis.","authors":"Omar Obeidat, Moh'd Daise, Qusai Alqudah, Mohammad Tarawneh, Hashim Al-Ani, Laith Alhuneafat, Ali Obeidat, Mohamed F Ismail, Abedallah Obeidat, Saeed Abughazaleh, Maria Obeidat, Jowan Al-Nusair, Ann Tong","doi":"10.1080/14796678.2026.2692606","DOIUrl":null,"url":null,"abstract":"Background: The association between breast cancer and coronary artery disease (CAD) remains important because of shared cardiovascular risk factors, potential cardiotoxic effects of cancer therapy, and the growing population of breast cancer survivors.Objective: To evaluate whether women with active or prior breast cancer have higher odds of CAD-related hospitalization using a nationally representative inpatient database.Methods: We conducted a retrospective analysis of the 2016-2019 National Inpatient Sample. Adult women aged 18 years or older with active or prior breast cancer were compared with women without breast cancer. The study included 589,940 unweighted breast cancer hospitalizations, representing 2,949,699 weighted hospitalizations, matched to an equal number of controls. Propensity score matching and multivariable logistic regression were used to adjust for demographic and clinical confounders, including hypertension, diabetes, chronic kidney disease, smoking, obesity, dyslipidemia, and prior myocardial infarction.Results: Breast cancer was not associated with increased odds of CAD-related hospitalization. In the unmatched cohort, breast cancer was associated with lower odds of CAD hospitalization (OR 0.84; 95% CI 0.84-0.85), attenuating after matching (OR 0.99; 95% CI 0.98-0.99). Lower odds were also observed for STEMI and NSTEMI hospitalizations.Conclusion: Breast cancer was not associated with increased odds of CAD-related hospitalization.","PeriodicalId":12589,"journal":{"name":"Future cardiology","volume":" ","pages":"717-725"},"PeriodicalIF":1.1000,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540095/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future cardiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/14796678.2026.2692606","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/7/6 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The association between breast cancer and coronary artery disease (CAD) remains important because of shared cardiovascular risk factors, potential cardiotoxic effects of cancer therapy, and the growing population of breast cancer survivors.

Objective: To evaluate whether women with active or prior breast cancer have higher odds of CAD-related hospitalization using a nationally representative inpatient database.

Methods: We conducted a retrospective analysis of the 2016-2019 National Inpatient Sample. Adult women aged 18 years or older with active or prior breast cancer were compared with women without breast cancer. The study included 589,940 unweighted breast cancer hospitalizations, representing 2,949,699 weighted hospitalizations, matched to an equal number of controls. Propensity score matching and multivariable logistic regression were used to adjust for demographic and clinical confounders, including hypertension, diabetes, chronic kidney disease, smoking, obesity, dyslipidemia, and prior myocardial infarction.

Results: Breast cancer was not associated with increased odds of CAD-related hospitalization. In the unmatched cohort, breast cancer was associated with lower odds of CAD hospitalization (OR 0.84; 95% CI 0.84-0.85), attenuating after matching (OR 0.99; 95% CI 0.98-0.99). Lower odds were also observed for STEMI and NSTEMI hospitalizations.

Conclusion: Breast cancer was not associated with increased odds of CAD-related hospitalization.

查看原文本刊更多论文

乳腺癌和冠状动脉疾病：来自全国住院病人样本分析的见解。

背景：乳腺癌和冠状动脉疾病（CAD）之间的关联仍然很重要，因为它们有共同的心血管危险因素，癌症治疗的潜在心脏毒性作用，以及乳腺癌幸存者人数的增加。目的：利用具有全国代表性的住院患者数据库，评估患有活动性乳腺癌或既往乳腺癌的女性是否有较高的cad相关住院几率。方法：对2016-2019年全国住院患者样本进行回顾性分析。研究人员将18岁及以上患有活动性或既往乳腺癌的成年女性与未患乳腺癌的女性进行比较。该研究包括589,940例未加权的乳腺癌住院病例，代表2,949,699例加权住院病例，与相同数量的对照组相匹配。倾向评分匹配和多变量logistic回归用于调整人口统计学和临床混杂因素，包括高血压、糖尿病、慢性肾病、吸烟、肥胖、血脂异常和既往心肌梗死。结果：乳腺癌与cad相关住院的几率增加无关。在未匹配的队列中，乳腺癌与较低的CAD住院几率相关（OR 0.84; 95% CI 0.84-0.85），匹配后降低（OR 0.99; 95% CI 0.98-0.99）。STEMI和NSTEMI住院的几率也较低。结论：乳腺癌与cad相关住院率增加无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.