Static Otolith Signals Reflect Clinical Course in Acute Vestibular Neuritis

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2026-10-02 Epub Date: 2026-07-07 DOI:10.1111/coa.70143

Seo-Young Choi, Jae-Hwan Choi, Hyun Sung Kim, Kwang-Dong Choi

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引用次数: 0

Abstract

Objectives

To investigate how static and dynamic utricular functions differentially correlate with dizziness symptoms and quality of life (QoL) recovery in patients with acute vestibular neuritis (VN).

Design

Prospective observational study with 1-week and 1-month follow-up assessments.

Setting

Tertiary referral centre.

Participants

Twenty-six patients diagnosed with acute VN were enrolled and evaluated at baseline, 1 week and 1 month after symptom onset.

Main Outcome Measures

Static utricular function was assessed using subjective visual vertical (SVV), and dynamic function via ocular vestibular-evoked myogenic potentials (oVEMP). Dizziness symptoms and QoL were evaluated using the Dizziness Handicap Inventory (DHI), Visual Analogue Scale (VAS) and the EQ-5D-5L questionnaire.

Results

Patients with normalised SVV tilt at 1 week showed significantly greater improvement in DHI scores compared to those with persistent abnormal SVV (p = 0.046). By 1 month, these patients demonstrated further significant improvement in both DHI (p = 0.012) and EQ-5D-5L (p = 0.035) scores. Furthermore, early improvement in SVV tilt correlated significantly with DHI improvement at 1 week (p = 0.048, Spearman's rho = 0.392). In contrast, dynamic utricular function as measured by oVEMP did not correlate with clinical recovery at any time point.

Conclusion

In acute VN, static utricular function correlates with early symptom relief and QoL recovery, whereas dynamic function does not. These findings suggest that central adaptive mechanisms may act more selectively on static utricular signals or recover dynamic pathways more rapidly.

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静态耳石信号反映急性前庭神经炎的临床过程。

目的：探讨静态和动态脑室功能与急性前庭神经炎（VN）患者头晕症状和生活质量（QoL）恢复的差异关系。设计：前瞻性观察研究，随访1周和1个月。单位：三级转介中心。参与者：26名诊断为急性VN的患者入组，并在症状出现后的基线、1周和1个月进行评估。主要结果测量：静态心室功能通过主观视觉垂直（SVV）评估，动态功能通过眼前庭诱发肌生成电位（oVEMP）评估。采用头晕障碍量表（DHI）、视觉模拟量表（VAS）和EQ-5D-5L问卷评估头晕症状和生活质量。结果：与SVV持续异常的患者相比，SVV倾斜正常化的患者在1周时DHI评分的改善明显更大（p = 0.046）。1个月后，这些患者的DHI （p = 0.012）和EQ-5D-5L （p = 0.035）评分均有进一步的显著改善。此外，SVV倾斜的早期改善与1周时DHI改善显著相关（p = 0.048, Spearman’s rho = 0.392）。相比之下，oVEMP测量的动态心室功能在任何时间点都与临床恢复无关。结论：在急性VN中，静态心室功能与早期症状缓解和生活质量恢复相关，而动态心室功能与早期症状缓解和生活质量恢复无关。这些发现表明，中枢自适应机制可能更有选择性地作用于静态的神经信号或更快地恢复动态通路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.