Preoperative breast MRI and long-term survival in ductal carcinoma in situ: a propensity score-weighted analysis.

IF 6 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Radiology Pub Date : 2026-11-01 Epub Date: 2026-07-06 DOI:10.1007/s00330-026-12720-3

Hee Jeong Kim, Woo Jung Choi, Ga Young Yoon, Hye Joung Eom, Eun Young Chae, Hee Jung Shin, Joo Hee Cha, Hak Hee Kim

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引用次数: 0

Abstract

Objectives: To assess the impact of preoperative MRI on long-term survival outcomes in women with ductal carcinoma in situ (DCIS).

Materials and methods: This retrospective study included women diagnosed with DCIS between January 2007 and December 2016. Propensity scores based on 25 demographic and clinicopathologic covariates were used to generate an overlap-weighted cohort, balancing patient groups according to MRI use. Recurrence-free survival (RFS) and overall survival (OS) were compared using Kaplan-Meier estimates with log-rank test and Cox proportional hazards models.

Results: Among 1003 eligible women (mean age, 48.6 years ± 9.4 [SD]), 624 (62.2%) underwent MRI. During a median follow-up of 9.5 years, 122 (12%) experienced recurrence, including 75 (61%) invasive events. The 15-year recurrence rates did not differ between the MRI and no-MRI groups (27% vs 23%; p = 0.77). Preoperative MRI was not associated with recurrence in the overlap-weighted cohort (hazard ratio (HR), 0.88 [95% CI: 0.60, 1.30]; p = 0.53). The 15-year overall mortality rate was 7% in both groups (p = 0.93), and preoperative MRI was not associated with overall mortality in the overlap-weighted cohort (HR, 1.21 [95% CI: 0.55, 2.66]; p = 0.64). Preoperative MRI was not an independent factor for RFS (HR, 0.99 [95% CI: 0.71, 1.39]; p = 0.95) or OS (HR, 1.11 [95% CI: 0.52, 2.37]; p = 0.78).

Conclusion: Preoperative breast MRI was not associated with improved RFS or OS among women with DCIS.

Key points: Question The impact of preoperative MRI on long-term outcomes in women with ductal carcinoma in situ (DCIS) remains uncertain. Findings In this retrospective propensity score-weighted analysis, preoperative breast MRI was not associated with improved recurrence-free survival or overall survival in women with DCIS. Clinical relevance Routine preoperative MRI may not improve long-term outcomes in DCIS. Prospective multicenter studies are warranted to identify subgroups that may derive meaningful survival benefits.

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导管原位癌术前乳腺MRI和长期生存率：倾向评分加权分析。

目的：评估术前MRI对导管原位癌（DCIS）患者长期生存结果的影响。材料和方法：本回顾性研究纳入2007年1月至2016年12月诊断为DCIS的女性。使用基于25个人口统计学和临床病理协变量的倾向得分来生成重叠加权队列，根据MRI使用平衡患者组。使用Kaplan-Meier估计、log-rank检验和Cox比例风险模型比较无复发生存期（RFS）和总生存期（OS）。结果：1003名符合条件的女性（平均年龄48.6岁±9.4 [SD]）中，624名（62.2%）接受了MRI检查。在中位9.5年的随访期间，122例（12%）复发，其中75例（61%）为侵袭性事件。MRI组和非MRI组的15年复发率没有差异（27% vs 23%; p = 0.77）。在重叠加权队列中，术前MRI与复发无关(风险比（HR）， 0.88 [95% CI: 0.60, 1.30]；p = 0.53)。两组患者的15年总死亡率均为7% (p = 0.93)，在重叠加权队列中，术前MRI与总死亡率无关（HR, 1.21 [95% CI: 0.55, 2.66]; p = 0.64）。术前MRI不是RFS （HR, 0.99 [95% CI: 0.71, 1.39]; p = 0.95）或OS （HR, 1.11 [95% CI: 0.52, 2.37]; p = 0.78）的独立因素。结论：术前乳腺MRI与DCIS患者的RFS或OS改善无关。术前MRI对导管原位癌（DCIS）患者长期预后的影响尚不确定。在这项回顾性倾向评分加权分析中，术前乳房MRI与DCIS患者无复发生存率或总生存率的改善无关。术前常规MRI可能不能改善DCIS的长期预后。有必要进行前瞻性多中心研究，以确定可能获得有意义的生存益处的亚组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Radiology 医学-核医学

CiteScore

11.60

自引率

8.50%

发文量

874

审稿时长

2-4 weeks

期刊介绍： European Radiology (ER) continuously updates scientific knowledge in radiology by publication of strong original articles and state-of-the-art reviews written by leading radiologists. A well balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes ER an indispensable source for current information in this field. This is the Journal of the European Society of Radiology, and the official journal of a number of societies. From 2004-2008 supplements to European Radiology were published under its companion, European Radiology Supplements, ISSN 1613-3749.