Exhausted CD8+ T cell subsets differ a TAD

IF 26.5 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2026-07-06 DOI:10.1038/s41590-026-02583-7

Maegan K. Murphy, Takeshi Egawa

引用次数: 0

Abstract

Lineage choices that maintain and diversify exhausted CD8+ T cells under chronic antigen exposure are driven by epigenetic rewiring. CTCF-mediated spatial chromatin reorganization is shown to regulate subset-specific architecture and gene expression programs, guiding differentiation of stem-like and effector exhausted CD8+ T cells.

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耗竭的CD8+ T细胞亚群不同于TAD。

在慢性抗原暴露下，维持和多样化耗尽的CD8+ T细胞的谱系选择是由表观遗传重新布线驱动的。ctcf介导的空间染色质重组被证明可以调节亚群特异性结构和基因表达程序，指导干细胞样和效应耗尽的CD8+ T细胞的分化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.