Rui Ke, Hai-Qiang Wang, Cheng-Yong Tan, Mi Li, Shi-Shan Yu
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Abstract
Four undescribed compounds, including one new sesquiterpene lactone (1, coriarilactone A), two new phenylpropanoid glycosides (2 and 3, corianosides A and B), and one new coumarin (4, coriacoumarin A), together with five known sesquiterpenes, were isolated from the leaves of the toxic medicinal plant Coriaria nepalensis. The structures of 1-4 were elucidated through a combination of extensive NMR spectroscopic analysis, HRESIMS, and X-ray crystallography. Notably, compounds 2-3 possess a rare heptose moiety, which were isolated from the Coriariaceae family for the first time. Compound 1 exhibited potential neuroprotective activity. All compounds showed no convulsant neurotoxicity and no remarkable inhibitory activity toward four human cancer cell lines.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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