Effect of the interaction between noise exposure and AGT gene polymorphisms in steelworkers on essential hypertension.

IF 2.7 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Archives of Occupational and Environmental Health Pub Date : 2026-07-06 DOI:10.1007/s00420-026-02222-6

Miao Liu, Ying Wang, Peishuai Li, Juxiang Yuan, Junwang Tong, Shoufang Jiang, Zhaoyang Wang, Yao Zheng, Feng Chai, Xiangwen Li

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引用次数: 0

Abstract

Purpose: Although steelworkers are exposed to occupational noise, few studies have investigated the interaction between noise and genetic polymorphisms in relation to essential hypertension (EH). This study aimed to investigate the interaction between noise exposure and angiotensinogen(AGT) gene polymorphisms (A-20 C and T174M) on EH risk among steelworkers.

Methods: The study included 725 male steelworkers, with 224 assigned to the EH group and 501 to the control group. The exposure to environmental factors such as high temperature and workplace noise levels were measured. Binary multifactorial logistic regression combined with crossover analysis and generalized multifactor dimensionality reduction (GMDR) were employed to examine the interaction effects between AGT gene polymorphisms and noise exposure on the incidence of EH among steelworkers.

Results: Compared with nonexposed controls, individuals who experienced noise exposure exhibited a 1.636-fold increased risk of developing EH (95% CI: 1.127-2.375). Genetic analysis revealed that compared with those with the TT genotype, steelworkers with the TM genotype at the T174M locus of the AGT gene exhibited a 1.802-fold increased risk of EH (95% CI: 1.208-2.689). Gene-noise interaction analysis using a multiplicative model revealed that compared with individuals with the TT genotype without noise exposure, individuals with the TM genotype at the T174M locus who experienced noise exposure exhibited a 2.02-fold increased risk of EH (OR = 2.020; 95% CI: 1.064-3.835). Analysis of the GMDR gene‒gene‒noise interaction model revealed that the T174M‒A-20C-noise three-factor model is the best.

Conclusion: Noise and AGT gene polymorphisms (especially T174M) interact to increase EH risk among steelworkers, with the three-factor model showing the strongest association.

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噪声暴露与钢铁工人AGT基因多态性相互作用对原发性高血压的影响。

目的：虽然钢铁工人暴露于职业性噪声中，但很少有研究调查噪声与原发性高血压（EH）相关的遗传多态性之间的相互作用。本研究旨在探讨噪声暴露与血管紧张素原（AGT）基因多态性（a - 20c和T174M）在钢铁工人EH风险中的相互作用。方法：选取725名男性钢铁工人为研究对象，其中EH组224人，对照组501人。研究人员测量了受高温和工作场所噪音等环境因素影响的程度。采用二元多因素logistic回归结合交叉分析和广义多因素降维（GMDR）方法，研究了AGT基因多态性与噪声暴露对钢铁工人EH发病率的交互作用。结果：与未接触噪音的对照组相比，接触噪音的个体患EH的风险增加了1.636倍（95% CI: 1.127-2.375）。遗传分析显示，与TT基因型相比，AGT基因T174M位点TM基因型的钢铁工人EH风险增加1.802倍（95% CI: 1.208 ~ 2.689）。利用乘法模型进行基因-噪声相互作用分析发现，与未暴露于噪声的TT基因型个体相比，暴露于噪声的T174M基因型个体发生EH的风险增加2.02倍（OR = 2.020; 95% CI: 1.064-3.835）。GMDR基因-基因-噪声相互作用模型分析表明，t174m - a - 20c -噪声三因子模型效果最佳。结论：噪声与AGT基因多态性（尤其是T174M）共同增加钢铁工人EH风险，其中三因素模型相关性最强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Archives of Occupational and Environmental Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

5.60

自引率

6.70%

发文量

127

审稿时长

3 months

期刊介绍： International Archives of Occupational and Environmental Health publishes Editorials, Review Articles, Original Articles, and Letters to the Editor. It welcomes any manuscripts dealing with occupational or ambient environmental problems, with a special interest in research at the interface of occupational health and clinical medicine. The scope ranges from Biological Monitoring to Dermatology, from Fibers and Dust to Human Toxicology, from Nanomaterials and Ultra-fine Dust to Night- and Shift Work, from Psycho-mental Distress and Burnout to Vibrations. A complete list of topics can be found on the right-hand side under For authors and editors. In addition, all papers should be based on present-day standards and relate to: -Clinical and epidemiological studies on morbidity and mortality -Clinical epidemiological studies on the parameters relevant to the estimation of health risks -Human experimental studies on environmental health effects. Animal experiments are only acceptable if relevant to pathogenic aspects. -Methods for studying the topics mentioned above.