In vivo biomechanical property detection of the ciliary muscle based on optical coherence tomography and digital image correlation technology.

IF 5.2 1区医学 Q1 OPHTHALMOLOGY

Eye and Vision Pub Date : 2026-07-06 DOI:10.1186/s40662-026-00498-w

Jingsong Wang, Shenglong Luo, Yixin Li, Shenao Yi, Ning Xu, Tong Wang, Yang Gao, Ruyu Yan, Fan Lu, Junjie Wang, Yilei Shao

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引用次数: 0

Abstract

Background: This study aimed to develop and validate a digital image correlation (DIC) methodology based on swept-source optical coherence tomography (SS-OCT) for quantifying in vivo ciliary muscle (CM) deformation and strain during accommodation.

Methods: This study was comprised of three phases. First, the measurement performance was examined across two SS-OCT systems (CASIA2 and VG200D) and four scanning modes (R1, R8, R16, and R64) by comparing the DIC-derived displacements with the simulated ground-truth fields. Second, reliability was validated using a "cross-image" strategy, in which artificial deformations were applied to biological images to assess tracking accuracy under realistic speckle noise. Third, 23 subjects were recruited and divided into three groups: control group (CN, n = 7), high myopia group (HM, n = 7), and elderly group (n = 9). Macroscopic morphological parameters (anterior CM length change and maximum CM thickness change) and biomechanical parameters (e.g., equivalent strain) were extracted synchronously.

Results: The R8 scanning mode in the CASIA2 device exhibited the most stable acquisition configuration. The robustness of the ncorr‑DIC algorithm was verified through the second-step experiment. Under the accommodative stimulus of - 5.0 D, the effective strain exhibited a highly significant graded attenuation among groups: CN (0.28 ± 0.06) > HM (0.20 ± 0.03) > Elderly (0.16 ± 0.05) (P = 0.002). Morphological changes were consistent with this finding, and CM thickening was significantly greater in the CN group than in the other two groups (P = 0.003). Combined analysis revealed that the mean effective strain was not only significantly positively correlated with macroscopic muscle thickening (r = 0.70, P < 0.001) but was also highly correlated with accommodation amplitude (r = 0.69, P < 0.001).

Conclusion: DIC-based OCT analysis is feasible for assessing the biomechanical response of CM. By quantifying mechanical attenuation associated with HM and age-related decline, this method provides a new functional biomarker for investigating the mechanisms of accommodation dysfunction and guiding clinical interventions.

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基于光学相干断层扫描和数字图像相关技术的睫状肌体内生物力学特性检测。

背景：本研究旨在开发和验证一种基于扫源光学相干断层扫描（SS-OCT）的数字图像相关（DIC）方法，用于量化体内睫状肌（CM）在调节过程中的变形和应变。方法：本研究分为三个阶段。首先，通过比较dic推导的位移和模拟的地真场，在两种SS-OCT系统（CASIA2和VG200D）和四种扫描模式（R1, R8， R16和R64）下测试了测量性能。其次，采用“交叉图像”策略验证可靠性，该策略将人工变形应用于生物图像，以评估在真实散斑噪声下的跟踪精度。第三，招募23名受试者，将其分为3组：对照组（CN, n = 7）、高度近视组（HM, n = 7）和老年组（n = 9）。同时提取宏观形态学参数（前CM长度变化和最大CM厚度变化）和生物力学参数（等效应变）。结果：R8扫描模式在CASIA2设备中表现出最稳定的采集构型。通过第二步实验验证了ncorr - DIC算法的鲁棒性。在- 5.0 D调节刺激下，各组有效应变呈极显著的梯度衰减：CN组（0.28±0.06）、HM组（0.20±0.03）、老年组（0.16±0.05）（P = 0.002）。形态学变化与这一发现一致，CN组CM增厚明显大于其他两组（P = 0.003）。综合分析发现，平均有效应变不仅与宏观肌肉增厚呈显著正相关（r = 0.70， P）。结论：基于dic的OCT分析是评估CM生物力学反应的可行方法。通过量化与HM和年龄相关衰退相关的机械衰减，该方法为研究调节功能障碍的机制和指导临床干预提供了新的功能生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye and Vision OPHTHALMOLOGY-

CiteScore

8.60

自引率

2.40%

发文量

审稿时长

15 weeks

期刊介绍： Eye and Vision is an open access, peer-reviewed journal for ophthalmologists and visual science specialists. It welcomes research articles, reviews, methodologies, commentaries, case reports, perspectives and short reports encompassing all aspects of eye and vision. Topics of interest include but are not limited to: current developments of theoretical, experimental and clinical investigations in ophthalmology, optometry and vision science which focus on novel and high-impact findings on central issues pertaining to biology, pathophysiology and etiology of eye diseases as well as advances in diagnostic techniques, surgical treatment, instrument updates, the latest drug findings, results of clinical trials and research findings. It aims to provide ophthalmologists and visual science specialists with the latest developments in theoretical, experimental and clinical investigations in eye and vision.