Baboon Syndrome Triggered by Diclofenac Potassium: A Case Report of Symmetrical Drug-Related Intertriginous and Flexural Exanthema.

IF 0.7 Q4 DERMATOLOGY

Case Reports in Dermatology Pub Date : 2026-05-08 eCollection Date: 2026-01-01 DOI:10.1159/000552458

Abdalwahab AlKanderi, Alsadat Mosbeh, Abeer A AlBazali, Ashok K Sharma

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Abstract

Introduction: Baboon syndrome, also known as symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), is a rare reaction characterised by distinct, bilateral erythema in the flexural and intertriginous regions, occurring without systemic symptoms.

Case presentation: We present a 53-year-old gentleman who, 3 days after commencing diclofenac potassium for knee pain, exhibited symmetrical, well-defined erythema affecting the neck, axillae, cubital and popliteal fossae, forearms, inguinal folds, thighs, legs, and feet. He displayed no systemic symptoms or fever. The time and distinctive distribution of SDRIFE induced by diclofenac potassium were congruent.

Management and outcome: Following the cessation of diclofenac potassium, the patient received topical corticosteroids and oral antihistamines. The symptoms resolved after 1 week.

Conclusion: This case highlights the necessity for physicians to identify this presentation for prompt diagnosis and care and also indicates diclofenac potassium as a possible cause of SDRIFE.

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双氯芬酸钾诱发狒狒综合征：对称性药物相关性三节间性和弯曲性皮疹1例报告。

简介：狒狒综合征，也被称为对称药物相关性三叉间和弯曲性皮疹（SDRIFE），是一种罕见的反应，其特征是在弯曲和三叉间区出现明显的双侧红斑，无全身性症状。病例介绍：我们报告了一位53岁的男士，他在开始双氯芬酸钾治疗膝关节疼痛3天后，表现出对称的，明确的红斑，影响颈部，腋窝，肘窝和腘窝，前臂，腹股沟褶皱，大腿，腿和脚。他没有出现全身症状或发烧。双氯芬酸钾诱导SDRIFE的时间和特征分布是一致的。治疗和结果：停止双氯芬酸钾治疗后，患者接受局部皮质类固醇和口服抗组胺药治疗。1周后症状消失。结论：该病例强调了医生识别这种表现以及时诊断和护理的必要性，也表明双氯芬酸钾可能是SDRIFE的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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