Serum anti-Müllerian hormone levels in women following bariatric surgery: insights from a systematic review and meta-analysis.

IF 3.7 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

BMC Endocrine Disorders Pub Date : 2026-07-04 DOI:10.1186/s12902-026-02394-9

Mohammad Sharifi, Mohammad Jalaeian Dehghani, Mohammad Amin Karimi, Ali Jafari

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引用次数: 0

Abstract

Aim: This systematic review and meta-analysis aimed to evaluate the effects of bariatric surgery on serum anti-Müllerian hormone (AMH) levels in women, highlighting potential implications for ovarian reserve and fertility management.

Methods: A systematic literature search was conducted in PubMed, Web of Science, Scopus, and Embase databases up to February 2025. The included studies were observational in design (cohort, case-control, cross-sectional) and provided quantitative pre- and post-operative AMH data. Quality assessment was performed using the Newcastle-Ottawa Scale, and data were analyzed using a random-effects meta-analysis.

Results: A total of 14 studies were included in the systematic review, with 591 participants contributing to the quantitative meta-analysis. The pooled results indicated that bariatric surgery did not significantly alter AMH levels overall (WMD = 0.05 ng/mL; 95% CI: -0.66, 0.75; p = 0.897), with substantial heterogeneity among effect estimates (I² = 93.9%, p < 0.001). Subgroup analyses suggested significant AMH reductions in studies with baseline AMH > 3 ng/mL, upper age limit ≤ 35 years, longer follow-up, retrospective design, smaller sample size, and South Asian populations, while a significant increase was observed in the fertile subgroup.

Conclusions: Bariatric surgery was not associated with a significant overall change in serum AMH levels. Findings suggest variable AMH responses across clinical and methodological contexts; however, given substantial heterogeneity and limited reproductive outcome data, these changes should be interpreted as dynamic endocrine biomarker responses rather than direct evidence of altered ovarian reserve or fertility potential.

Clinical trial number: Not applicable.

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减肥手术后女性血清抗勒氏杆菌激素水平：来自系统回顾和荟萃分析的见解

目的：本系统综述和荟萃分析旨在评估减肥手术对女性血清抗勒氏杆菌激素（AMH）水平的影响，强调对卵巢储备和生育管理的潜在影响。方法：系统检索截至2025年2月的PubMed、Web of Science、Scopus和Embase数据库的文献。纳入的研究采用观察性设计（队列、病例对照、横断面），并提供了定量的术前和术后AMH数据。使用纽卡斯尔-渥太华量表进行质量评估，并使用随机效应荟萃分析分析数据。结果：系统评价共纳入14项研究，591名参与者参与了定量荟萃分析。综合结果显示，减肥手术总体上没有显著改变AMH水平（WMD = 0.05 ng/mL; 95% CI: -0.66, 0.75; p = 0.897），在效果估计中存在显著异质性（I²= 93.9%,p 3 ng/mL，年龄上限≤35岁，随访时间较长，回顾性设计，样本量较小，南亚人群），而在生育亚组中观察到显著增加。结论：减肥手术与血清AMH水平的显著总体变化无关。研究结果表明，在临床和方法学背景下，AMH的反应是可变的；然而，考虑到大量的异质性和有限的生殖结果数据，这些变化应该被解释为动态内分泌生物标志物反应，而不是卵巢储备或生育潜力改变的直接证据。临床试验号：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.