Brief communication: clinical jaundice is associated with poor adherence to boosted atazanavir among adults in an HIV clinic in Kampala, Uganda.

IF 2.8 4区医学 Q3 INFECTIOUS DISEASES

AIDS Research and Therapy Pub Date : 2026-07-04 DOI:10.1186/s12981-026-00908-y

Angella Nabakooza, Sharon Kitibwakye Nakamanya, Eva Agnes Laker, Elizabeth Katana, Noela Owarwo, Isaac Lwanga, Barbara Castelnuovo, Mohammed Lamorde, Freddy Kitutu Eric

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引用次数: 0

Abstract

Background: Boosted atazanavir (ATV/r) is associated with clinical jaundice, which may affect ART adherence. However, the prevalence of clinical jaundice among people on ATV/r and its association with ART adherence is unknown in Uganda.

Methods: We conducted a cross-sectional study among 236 adult patients on ATV/r at the Infectious Disease Institute. Clinical jaundice was assessed by self-report and observation; ART adherence was measured using the 8-item Morisky scale.

Results: Period prevalence of clinical jaundice was 31.8%, while point prevalence was 21.1%. While 8.5% had poor adherence, clinical jaundice was a significant predictor of poor adherence (adjusted odds ratio = 3.03, 95% CI: 1.18-7.76, p = 0.021).

Conclusion: Clinical jaundice is common among patients on ATV/r in Uganda and is associated with poor ART adherence. Strengthening pre-ATV/r (pre-switch) counselling and exploring safer regimen alternatives are required to improve outcomes.

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简短交流：在乌干达坎帕拉的一家艾滋病毒诊所中，临床黄疸与成人对阿扎那韦强化治疗依从性差有关。

背景：阿扎那韦（ATV/r）增强与临床黄疸有关，这可能影响抗逆转录病毒治疗的依从性。然而，在乌干达，临床黄疸在ATV/r患者中的流行程度及其与抗逆转录病毒治疗依从性的关系尚不清楚。方法：我们对传染病研究所236例ATV/r成年患者进行了横断面研究。采用自我报告法和观察法评估临床黄疸；ART依从性采用8项Morisky量表进行测量。结果：临床黄疸期患病率为31.8%，点患病率为21.1%。8.5%的患者依从性差，临床黄疸是依从性差的显著预测因子（校正优势比= 3.03,95% CI: 1.18-7.76, p = 0.021）。结论：临床黄疸在乌干达的ATV/r患者中很常见，并且与抗逆转录病毒治疗依从性差有关。需要加强atv /r（转换前）前咨询并探索更安全的替代方案，以改善结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS Research and Therapy INFECTIOUS DISEASES-

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

16 weeks

期刊介绍： AIDS Research and Therapy publishes articles on basic science, translational, clinical, social, epidemiological, behavioral and educational sciences articles focused on the treatment and prevention of HIV/AIDS, and the search for the cure. The Journal publishes articles on novel and developing treatment strategies for AIDS as well as on the outcomes of established treatment strategies. Original research articles on animal models that form an essential part of the AIDS treatment research are also considered