Diagnosis and Staging of Patients with Prostate Cancer: Report from the 2025 Advanced Prostate Cancer Consensus Conference (APCCC) Diagnostics

IF 29.1 1区医学 Q1 UROLOGY & NEPHROLOGY

European urology Pub Date : 2026-10-01 Epub Date: 2026-07-03 DOI:10.1016/j.eururo.2026.06.009

Stefano Fanti, Fabio Turco, Bertrand Tombal, Jochen Walz, Michael S. Hofman, Boris Hadaschik, Louise Emmett, Derya Tilki, Giovanna Pecoraro, Giuseppe Salfi, Gerhardt Attard, Himisha Beltran, Anders Bjartell, Alberto Briganti, Irene A. Burger, Elena Castro, Juliano J. Cerci, Arturo Chiti, Matthew Cooperberg, Karim Fizazi, Ken Herrmann

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引用次数: 0

Abstract

Background and objective:

For over a decade the Advanced Prostate Cancer Consensus Conference (APCCC) covers a variety of topics that greatly impact daily practice. In 2025, a dedicated event was organised to discuss key questions in clinical management of patients with prostate cancer (PC) related to diagnostic tools (APCCC Diagnostics). Here we present the voting results of the APCCC Diagnostics questions.

Methods:

APCCC Diagnostics 2025 is a pilot project. The scientific committee for APCCC Diagnostics 2025 developed 88 multiple-choice consensus questions on six different topics. Prior to the conference, the panel members (‘‘panellists’’) voted on these questions via a web-based survey. Consensus was defined as ≥75% agreement, with strong consensus defined as ≥90% agreement.

Key findings and limitations:

Consensus was only reached on 17 of 88 questions (19%), of which six (7%) received a strong consensus. Specifically, consensus was reached for two of 17 questions (14%) in “how to diagnose PC”; seven of 16 (44%) in “how to stage PC”; three of 14 (21%) in “Biochemical Recurrence Scenario”; two of 11 (18%) in “metastatic disease: what to do?”; zero of 18 (0%) in “monitoring metastatic PC”; and three of 12 (25%) in “radioligand therapy and imaging.”

Conclusions and clinical implications:

The voting results and their discussion may assist physicians in navigating controversial areas of clinical management related to diagnosis, staging, and restaging in the different clinical settings for PC, particularly where high-level evidence is scarce or conflicting. The findings can also help funders and policymakers in prioritising areas for future research.

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前列腺癌患者的诊断和分期：2025年晚期前列腺癌共识会议（APCCC）诊断报告

背景：十多年来，晚期前列腺癌共识会议（APCCC）涵盖了各种主题，极大地影响了日常实践。2025年，组织了一个专门的活动，讨论与诊断工具（APCCC Diagnostics）相关的前列腺癌（PC）患者临床管理中的关键问题。这里我们展示了APCCC诊断问题的投票结果。客观的;设计、设置和参与者：APCCC诊断2025是一个试点项目。APCCC诊断2025科学委员会针对6个不同主题制定了88个选择题。在会议之前，小组成员（“小组成员”）通过网络调查对这些问题进行投票。一致定义为≥75%的一致，强一致定义为≥90%的一致。结果测量和统计分析：88个问题中只有17个（19%）达成了共识，其中6个（7%）获得了强烈的共识。具体来说，在“如何诊断PC”的17个问题中，有两个问题（14%）达成了共识；16人中有7人（44%）回答“如何搭建PC”；“生化复发情景”14例中有3例（21%）；“转移性疾病：该怎么办？”11例中有2例（18%）；“监测转移性PC”的比例为18 (0%)；12人中有3人（25%）在“放射配体治疗和成像”中。结论：投票结果和他们的讨论可能有助于医生在临床管理中与诊断、分期和在不同临床环境中重新定位相关的争议领域，特别是在高水平证据稀缺或相互矛盾的情况下。这些发现还可以帮助资助者和决策者确定未来研究的优先领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European urology 医学-泌尿学与肾脏学

CiteScore

43.00

自引率

2.60%

发文量

1753

审稿时长

23 days

期刊介绍： European Urology is a peer-reviewed journal that publishes original articles and reviews on a broad spectrum of urological issues. Covering topics such as oncology, impotence, infertility, pediatrics, lithiasis and endourology, the journal also highlights recent advances in techniques, instrumentation, surgery, and pediatric urology. This comprehensive approach provides readers with an in-depth guide to international developments in urology.