A planar binuclear Cadmium(II)-Acylhydrazone Schiff base complex as a potent DNA-targeted anticancer agent

IF 2.8 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Transition Metal Chemistry Pub Date : 2026-06-29 DOI:10.1007/s11243-026-00740-3

Jun Wang, Peiyu Peng, Xuexue Pan, Wenhua Zhao, Qamar Abbas

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Abstract

This study developed a planar binuclear Cd(II) acylhydrazone Schiff base complex as a novel DNA-targeted anti-tumour agent. The complex was synthesised via a one-pot reaction of the ligand HL with cadmium nitrate. X-ray crystallography revealed a centrosymmetric structure, with each Cd(II) ion in a seven-coordinate geometry, forming a rigid planar system through phenoxide bridging. Spectroscopic analyses confirmed ligand-to-ligand charge transfer fluorescence with a lifetime of 5.746 ns, attributed to enhanced rigidity upon coordination. DNA binding studies demonstrated that the complex intercalates strongly into CT-DNA, with a high binding constant (Kb = 4.85 × 10⁵ M^-1), significantly greater than that of the free ligand. In vitro assays showed the complex exhibits potent, concentration-dependent anti-proliferative activity against A549 and MCF-7 cancer cells (IC₅₀ = 10.88 µM and 5.28 µM, respectively), effectively inducing apoptosis, unlike the weak ligand. This planar binuclear Cd(II) complex is a promising candidate for the development of new metal-based anticancer drugs.

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平面双核镉(II)-酰基腙希夫碱配合物作为一种有效的dna靶向抗癌剂

本研究开发了一种平面双核Cd（II）酰基腙希夫碱配合物，作为一种新的dna靶向抗肿瘤药物。该配合物是通过配体HL与硝酸镉的一锅反应合成的。x射线晶体学揭示了一个中心对称结构，每个Cd（II）离子在七坐标几何结构中，通过苯氧化合物桥接形成一个刚性平面体系。光谱分析证实配体-配体电荷转移荧光的寿命为5.746 ns，归因于配位时增强的刚性。DNA结合研究表明，该配合物与CT-DNA有较强的插层关系，具有较高的结合常数（Kb = 4.85 × 105 M-1），明显大于游离配体。体外实验表明，与弱配体不同，该复合物对A549和MCF-7癌细胞具有强效、浓度依赖性的抗增殖活性（IC50分别为10.88µM和5.28µM），能有效诱导细胞凋亡。这种平面双核Cd（II）配合物是开发新型金属基抗癌药物的有希望的候选物。

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来源期刊

Transition Metal Chemistry 化学-无机化学与核化学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

1.3 months

期刊介绍： Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc. Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.