A breath of fresh AIR in novel CAR T cell design

IF 16.4 1区医学 Q1 IMMUNOLOGY

Science Immunology Pub Date : 2026-07-03 DOI:10.1126/sciimmunol.aej9802

Bin-Bin Schell, Laura Solt

引用次数: 0

Abstract

Insertion of a compact motif into CARs enables activation-induced receptor shedding, thereby enhancing CAR T cell potency.

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在新颖的CAR - T细胞设计中呼吸新鲜空气。

将一个紧凑的基序插入到CAR中可以激活诱导的受体脱落，从而增强CAR - T细胞的效力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Immunology Immunology and Microbiology-Immunology

CiteScore

32.90

自引率

2.00%

发文量

183

期刊介绍： Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.