Serological evidence of hepatitis B virus exposure and vaccination coverage trends in health sciences students in Albania.

世界病毒学杂志(英文版) Pub Date : 2026-06-25 DOI:10.5501/wjv.v15.i2.118992

Jerina Jaho, Luçiano Balilaj, Ani Bulla, Ylenia Capraro, Leonard Lamfu, Leonardo Baiocchi

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Abstract

Background: Hepatitis B virus remains an important occupational risk for healthcare trainees. Objective serology can verify protection and inform pre-placement clearance policies.

Aim: To assess hepatitis B vaccination status, occupational exposure, and serological protection among health sciences students in Albania.

Methods: Cross-sectional study (April-June 2024) at the University of Vlore. Students completed a structured questionnaire (n = 152); a consenting subset provided blood samples for hepatitis B surface antigen and anti-hepatitis B surface antibody (HBs) testing (n = 134). Group comparisons used χ ²/Fisher's exact tests and multivariable logistic regression for seroprotection (anti-HBs ≥ 10 IU/L).

Results: All tested participants were hepatitis B surface antigen negative (n = 134). Overall, 86.6% had protective anti-HBs (≥ 10 IU/L), including 76.2% with titers > 100 IU/L; 13.4% had anti-HBs < 10 IU/L. Needlestick/sharps injuries were reported during training, supporting the need for standardized clearance and reporting pathways.

Conclusion: Most students had serological protection, but a meaningful minority lacked protective titers. Universities and training sites should implement pre-placement HB clearance with documented vaccination, mandatory anti-HBs testing, and structured catch-up/booster pathways.

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阿尔巴尼亚卫生科学学生乙型肝炎病毒暴露和疫苗接种覆盖率趋势的血清学证据

背景：乙型肝炎病毒仍然是卫生保健受训人员的一个重要职业风险。目的血清学可以验证保护和告知放置前清除政策。目的：评估阿尔巴尼亚卫生科学专业学生的乙型肝炎疫苗接种状况、职业暴露和血清学保护。方法：横断面研究（2024年4月- 6月）在伏洛雷大学。学生完成了一份结构化问卷（n = 152）；一组同意提供血液样本进行乙型肝炎表面抗原和抗乙型肝炎表面抗体（HBs）检测（n = 134）。组间比较采用χ 2/Fisher精确检验和多变量logistic回归进行血清保护（anti-HBs≥10 IU/L）。结果：所有受试者均为乙型肝炎表面抗原阴性（n = 134）。总体而言，86.6%的人具有保护性抗- hbs(≥10 IU/L)，其中76.2%的人滴度为100 IU/L；13.4%的人抗hbs < 10 IU/L。在训练期间报告了针刺/锐器伤害，这支持了标准化清除和报告途径的必要性。结论：大多数学生有血清学保护，但有意义的少数缺乏保护滴度。大学和培训机构应该通过记录的疫苗接种、强制性的抗乙型肝炎病毒检测和结构化的追赶/加强途径来实施安置前乙型肝炎病毒清除。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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世界病毒学杂志(英文版)

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