{"title":"[Progress in basic research on hydrogel-based drug delivery systems for the treatment of peri-implantitis].","authors":"M K Liu, Z H Zhang, L Lang, H H Liu","doi":"10.3760/cma.j.cn112144-20251012-00399","DOIUrl":null,"url":null,"abstract":"<p><p>Peri-implantitis is a common complication following oral implantation that seriously jeopardizes long-term implant stability and prosthetic outcomes. Conventional therapeutic modalities, including non-surgical and surgical interventions, exhibit inherent limitations. Hydrogel-based drug delivery systems (hDDSs), as an emerging platform, are increasingly recognized for their therapeutic potential of favorable biocompatibility, sustained drug-release kinetics, and advantage of local administration in basic studies of peri-implantitis, thus offering broad translational prospects. This review outlines the hDDSs currently employed in peri-implantitis research and summarizes the latest advances. Moreover, we analyze and compare the strengths and limitations of various hydrogel drug-loading strategies, discuss the challenges hindering clinical translation, aiming to provide guidance and inspiration for future clinical management and research of peri-implantitis.</p>","PeriodicalId":23965,"journal":{"name":"中华口腔医学杂志","volume":"61 7","pages":"1066-1073"},"PeriodicalIF":0.0000,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华口腔医学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/cma.j.cn112144-20251012-00399","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Peri-implantitis is a common complication following oral implantation that seriously jeopardizes long-term implant stability and prosthetic outcomes. Conventional therapeutic modalities, including non-surgical and surgical interventions, exhibit inherent limitations. Hydrogel-based drug delivery systems (hDDSs), as an emerging platform, are increasingly recognized for their therapeutic potential of favorable biocompatibility, sustained drug-release kinetics, and advantage of local administration in basic studies of peri-implantitis, thus offering broad translational prospects. This review outlines the hDDSs currently employed in peri-implantitis research and summarizes the latest advances. Moreover, we analyze and compare the strengths and limitations of various hydrogel drug-loading strategies, discuss the challenges hindering clinical translation, aiming to provide guidance and inspiration for future clinical management and research of peri-implantitis.
期刊介绍：
Founded in August 1953, Chinese Journal of Stomatology is a monthly academic journal of stomatology published publicly at home and abroad, sponsored by the Chinese Medical Association and co-sponsored by the Chinese Stomatology Association. It mainly reports the leading scientific research results and clinical diagnosis and treatment experience in the field of oral medicine, as well as the basic theoretical research that has a guiding role in oral clinical practice and is closely combined with oral clinical practice.
Chinese Journal of Over the years, Stomatology has been published in Medline, Scopus database, Toxicology Abstracts Database, Chemical Abstracts Database, American Cancer database, Russian Abstracts database, China Core Journal of Science and Technology, Peking University Core Journal, CSCD and other more than 20 important journals at home and abroad Physical medicine database and retrieval system included.
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