Escaping the trap

IF 60.7 1区医学 Q1 ONCOLOGY

Nature Reviews Cancer Pub Date : 2026-07-02 DOI:10.1038/s41568-026-00957-5

Daniela Senft

引用次数: 0

Abstract

A recent study identifies TEX264-dependent nucleophagy as an important mechanism that mediates the clearance of trapped PARP1, thereby limiting PARP1-induced toxicity and promoting resistance to PARP inhibitors.

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逃离陷阱。

最近的一项研究发现，依赖tex264的核自噬是介导被困PARP1清除的重要机制，从而限制PARP1诱导的毒性并促进对PARP抑制剂的抗性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.