Curcumin as a Multifaceted Epigenetic Modulator With a Disease-Oriented Perspective.

IF 8.1 2区医学 Q1 CHEMISTRY, MEDICINAL

Phytotherapy Research Pub Date : 2026-10-01 Epub Date: 2026-07-02 DOI:10.1002/ptr.70401

Hedieh Sadat Shamsnia, Mahtab Roustaei, Amirreza Peyrovinasab, Mazyar Ataei, Fatemeh Shafiean, Mohammadmahdi Ghavamipour Komleh, Mobina Tajdari, Mohammad Mahdi Khosravi Nia, Sayna Sadeghi Kivi, Amir Hossein Abdolghaffari

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Abstract

Curcumin (diferuloylmethane), a polyphenolic compound, is a component of Curcuma longa , commonly known as turmeric. It is well known for its therapeutic properties in a variety of diseases. One of its distinctive mechanisms is epigenetic modification. Epigenetic changes involve alterations in DNA methylation, histone modifications, and non-coding RNA expression patterns, which are interconnected and play a crucial role in various pathologies. It has been shown that curcumin inhibits DNA methyltransferases (DNMT), thereby reversing abnormal hypermethylation and reactivating silenced genes. Concurrently, it downregulates histone deacetylases (HDACs), promotes histone acetyltransferase (HAT) activity, and modulates the expression of non-coding RNAs, including miRNAs. Consequently, curcumin regulates many mechanisms, including inflammatory cascades, oxidative stress responses, and neuronal function. Curcumin's broad-spectrum activity has been demonstrated in various pathologies. For instance, in cancer, it modulates epigenetic mechanisms to support tumor suppression; in neurodegenerative diseases, it enhances neuronal survival; and in metabolic disorders, it improves insulin responsiveness. It also reduces inflammation and fibrosis in cardiovascular, hepatic, renal, and inflammatory conditions. This review will describe curcumin's diverse role as an epigenetic modulator from a novel disease-oriented perspective.

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姜黄素作为一种多面表观遗传调节剂与疾病取向的观点。

姜黄素是一种多酚化合物，是姜黄（俗称姜黄）的一种成分。它以其治疗多种疾病的特性而闻名。其独特的机制之一是表观遗传修饰。表观遗传变化包括DNA甲基化、组蛋白修饰和非编码RNA表达模式的改变，这些变化相互关联，在各种病理中起着至关重要的作用。研究表明，姜黄素抑制DNA甲基转移酶（DNMT），从而逆转异常的高甲基化和重新激活沉默基因。同时，它下调组蛋白去乙酰化酶（hdac），促进组蛋白乙酰转移酶（HAT）活性，并调节包括mirna在内的非编码rna的表达。因此，姜黄素调节许多机制，包括炎症级联反应、氧化应激反应和神经元功能。姜黄素的广谱活性已在各种疾病中得到证实。例如，在癌症中，它调节表观遗传机制以支持肿瘤抑制；在神经退行性疾病中，它能提高神经元的存活率；在代谢紊乱中，它能改善胰岛素的反应性。它还可以减少心血管、肝脏、肾脏和炎症的炎症和纤维化。本文将从一个新的疾病导向的角度来描述姜黄素作为表观遗传调节剂的多种作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytotherapy Research 医学-药学

CiteScore

12.80

自引率

5.60%

发文量

325

审稿时长

2.6 months

期刊介绍： Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field. Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters. By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.