Comparative Analysis of CEM and Breast MRI: A Retrospective Study

IF 1.9 3区医学 Q3 ONCOLOGY

Journal of Surgical Oncology Pub Date : 2026-09-14 Epub Date: 2026-07-02 DOI:10.1002/jso.70315

Joanna Tomala, Neil Upadhyay

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引用次数: 0

Abstract

Introduction

Breast cancer is a prevalent malignancy where accurate preoperative assessment is crucial for treatment planning. Breast MRI is a highly sensitive imaging modality for breast cancer detection. It is widely used preoperatively and can assist with local staging, tumour size assessment, detection of additional tumour foci and assessment of treatment response in patients receiving neoadjuvant chemotherapy. Contrast-enhanced spectral mammography (CEM) is an emerging alternative with comparable diagnostic performance and shorter examination times. This study retrospectively compares CEM and MRI in measuring breast cancer extent.

Methods

In this retrospective study conducted at Imperial College Healthcare NHS Trust, 58 patients with histologically confirmed breast cancer who underwent both CEM and MRI between January 2020 and July 2023 were included. Lesion sizes were evaluated on both modalities and compared with the postoperative histopathology specimen using the Wilcoxon signed-rank test and Pearson correlation.

Results

There was no statistically significant difference in average tumour size between CEM and MRI (28.8 mm (SD = 22.8) on CEM and 31.8 mm (SD = 24.2) on MRI; p = 0.1058). Both imaging modalities demonstrated similar measurement precision when compared with the surgical specimen (12.9 mm vs. 12.2 mm absolute mean difference between histopathological and radiological measurement – MRI and CEM respectively). Pearson analysis demonstrated a good correlation with postoperative histopathology in size measurement, with CEM showing slightly stronger correlation (r = 0.7858, p < 0.0001, n = 45) compared with MRI (r = 0.6726, p < 0.0001, n = 46).

Discussion

CEM appears to be a viable alternative to MRI. This study demonstrates high sensitivity of CEM and MRI for breast cancer detection, with no statistically significant difference in maximum diameter of enhancing abnormalities. Both modalities strongly correlate with histopathology. Further studies are required to validate the role of CEM in clinical practice.

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CEM与乳腺MRI对比分析：一项回顾性研究。

乳腺癌是一种常见的恶性肿瘤，准确的术前评估对治疗计划至关重要。乳腺MRI是一种高度敏感的乳腺癌检测成像方式。它被广泛应用于术前，可以帮助接受新辅助化疗的患者进行局部分期、肿瘤大小评估、附加肿瘤灶的检测和治疗反应评估。对比增强光谱乳房x线照相术（CEM）是一种新兴的替代方法，具有相当的诊断性能和更短的检查时间。本研究回顾性比较脑电成像和磁共振成像测量乳腺癌的范围。方法：在这项由帝国理工学院医疗保健NHS信托进行的回顾性研究中，纳入了58例组织学证实的乳腺癌患者，这些患者在2020年1月至2023年7月期间接受了CEM和MRI检查。用两种方法评估病变大小，并使用Wilcoxon符号秩检验和Pearson相关性与术后组织病理学标本进行比较。结果：CEM与MRI的平均肿瘤大小差异无统计学意义(CEM为28.8 mm (SD = 22.8)， MRI为31.8 mm (SD = 24.2)；p = 0.1058)。与手术标本相比，两种成像方式显示出相似的测量精度（组织病理学和放射学测量- MRI和CEM分别为12.9 mm和12.2 mm的绝对平均差异）。Pearson分析显示，在尺寸测量方面，CEM与术后组织病理学有良好的相关性，CEM的相关性稍强（r = 0.7858, p）。本研究显示CEM与MRI对乳腺癌的检测灵敏度较高，增强异常最大直径差异无统计学意义。这两种模式都与组织病理学密切相关。需要进一步的研究来验证CEM在临床实践中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.