{"title":"Effects of gabapentin on heroin and cocaine self-administration in rats.","authors":"Shawn M Flynn, Han Namgoong, Charles P France","doi":"10.1097/FBP.0000000000000884","DOIUrl":null,"url":null,"abstract":"<p><p>Reports of gabapentin misuse among people with opioid use disorder have increased, as has the presence of gabapentin in opioid overdose deaths. Despite these trends and known interactions between these drugs in other settings (e.g. gabapentin as an 'opioid-sparing' agent), few studies have evaluated the impact of gabapentin on reinforcing effects of opioids. Intravenous self-administration in rats was used to determine whether gabapentin modifies the reinforcing effects of heroin or cocaine. Rats self-administered drugs under a progressive ratio schedule of reinforcement after saline or gabapentin pretreatment. Pretreatment with 32 mg/kg gabapentin increased the number of infusions earned on the ascending limb of the heroin dose-response curve but had no effect on cocaine self-administration. While the magnitude of effect was modest, these data suggest that gabapentin can potentiate the reinforcing effects of opioids and lays the groundwork for future studies characterizing interactions between gabapentinoids and opioids in the context of reinforcement.</p>","PeriodicalId":8832,"journal":{"name":"Behavioural Pharmacology","volume":"37 4","pages":"164-168"},"PeriodicalIF":1.4000,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Behavioural Pharmacology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1097/FBP.0000000000000884","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/7/1 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Reports of gabapentin misuse among people with opioid use disorder have increased, as has the presence of gabapentin in opioid overdose deaths. Despite these trends and known interactions between these drugs in other settings (e.g. gabapentin as an 'opioid-sparing' agent), few studies have evaluated the impact of gabapentin on reinforcing effects of opioids. Intravenous self-administration in rats was used to determine whether gabapentin modifies the reinforcing effects of heroin or cocaine. Rats self-administered drugs under a progressive ratio schedule of reinforcement after saline or gabapentin pretreatment. Pretreatment with 32 mg/kg gabapentin increased the number of infusions earned on the ascending limb of the heroin dose-response curve but had no effect on cocaine self-administration. While the magnitude of effect was modest, these data suggest that gabapentin can potentiate the reinforcing effects of opioids and lays the groundwork for future studies characterizing interactions between gabapentinoids and opioids in the context of reinforcement.
期刊介绍：
Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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