Peptideins: Navigating the gray zone of the proteome

IF 14.4 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2026-09-01 Epub Date: 2026-07-02 DOI:10.1016/j.tibs.2026.06.004

Giulia Pesce, Salvador Ventura

引用次数: 0

Abstract

Translated sequences are often treated as either genes or noise. A recent TransCODE Consortium study by Deutsch et al. introduces peptideins: endogenous proteins with evidence of synthesis but an unresolved biological status. This concept offers a cautious way to expand the human proteome while preserving the distinction between translation, molecular detection, and function.

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肽素：导航蛋白质组的灰色地带。

翻译序列通常被视为基因或噪声。最近由Deutsch等人进行的TransCODE Consortium研究介绍了肽素：一种内源性蛋白质，具有合成证据，但生物学状态尚未确定。这一概念为扩展人类蛋白质组提供了一种谨慎的方法，同时保留了翻译、分子检测和功能之间的区别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.