Modeling human hypothalamic cell diversity through developmental patterning.

IF 23.3 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2026-07-02 DOI:10.1016/j.stem.2026.06.003

Sol Díaz de León-Guerrero,Zhiping P Pang

引用次数: 0

Abstract

Understanding the cellular diversity of the human hypothalamus has been limited by the lack of accessible models. In this issue of Cell Stem Cell, Abay-Nørgaard et al.1 demonstrate that temporal control of BMP signaling during human pluripotent stem cell differentiation generates diverse hypothalamic populations, providing a platform to study human hypothalamic development and function.

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通过发育模式模拟人类下丘脑细胞多样性。

由于缺乏可接近的模型，对人类下丘脑细胞多样性的了解一直受到限制。在这一期的Cell Stem Cell中，Abay-Nørgaard et al.1证明了人类多能干细胞分化过程中BMP信号的时间控制产生了不同的下丘脑群体，为研究人类下丘脑的发育和功能提供了平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.