Exploring the role of the NLRP3 Inflammasome in polycystic ovary syndrome: therapeutic potential of herbal medicines.

IF 5.3 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research Pub Date : 2026-07-02 DOI:10.1186/s13048-026-02187-7

Shayan Vafaei, Reyhane Naghibzade, Ghazaleh Moshkdanian, Hossein Nikzad, Golnaz Shafiei, Mahna Mansoori

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Abstract

Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders in women during their reproductive years and is associated with a wide range of reproductive, metabolic, and psychological complications. This review aims to synthesize current knowledge regarding the complex pathophysiology of PCOS, focusing on the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome's role in mediating inflammation and metabolic dysfunction. Additionally, we explore the therapeutic potential of herbal medicines in modulating the NLRP3 pathway, highlighting their multi-targeted mechanisms of action. The bioactive compounds derived from various medicinal plants may effectively regulate NLRP3 inflammasome activation, thereby alleviating the symptoms associated with PCOS. As PCOS continues to pose significant health challenges for women worldwide, this review emphasizes the necessity for innovative therapeutic strategies that integrate traditional knowledge with modern scientific approaches.

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探讨NLRP3炎性体在多囊卵巢综合征中的作用：草药的治疗潜力。

多囊卵巢综合征（PCOS）是育龄期女性最常见的内分泌疾病之一，与多种生殖、代谢和心理并发症有关。本文旨在综合目前关于多囊卵巢综合征复杂病理生理的知识，重点介绍nod样受体pyrin结构域- 3 （NLRP3）炎症小体在介导炎症和代谢功能障碍中的作用。此外，我们探索了草药在调节NLRP3通路方面的治疗潜力，强调了它们的多靶点作用机制。来自多种药用植物的生物活性化合物可有效调节NLRP3炎性体的激活，从而缓解PCOS相关症状。由于多囊卵巢综合征继续对全球妇女的健康构成重大挑战，本综述强调了将传统知识与现代科学方法相结合的创新治疗策略的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.