Intrapulmonary solitary fibrous tumor: clinicopathological analysis of 29 cases with emphasis on morphological spectrum and immunohistochemical profile.

IF 3.5 3区医学 Q2 PATHOLOGY

Diagnostic Pathology Pub Date : 2026-07-01 DOI:10.1186/s13000-026-01800-z

Xin Zeng, Xiaodong Lin, Lifang Ye, Zhenyong Wu, Zeyun Lin, Shuting Li

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引用次数: 0

Abstract

Background: Intrapulmonary solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm that can mimic pulmonary adenofibroma (PAF) when respiratory epithelium is entrapped.

Methods: We retrospectively analyzed 29 intrapulmonary SFTs, reviewing clinical, histopathological, and immunohistochemical features. STAT6, CD34, ER, and PR were evaluated.

Results: The cohort included 18 males and 11 females (mean age 55.3 years); 69.0% were asymptomatic. Mean tumor size was 4.11 cm, with pleural attachment in 62.1%. Histologically, 79.3% showed biphasic cellularity, 86.2% had staghorn vessels, and 44.8% exhibited entrapped epithelium. Stromal changes included collagenization (89.7%), hemorrhage (24.1%), myxoid change (20.7%), cystic change (6.9%), and multinucleated giant cells (3.4%). Risk stratification identified 25 low-risk, three intermediate-risk, and one high-risk case. STAT6 was positive in all tested cases (28/28, 100%), and CD34 in 96.3%. Among 22 evaluable cases, 19 (86.4%) showed ER < PR. During a mean follow-up of 36.7 months, one high-risk patient (3.4%) developed local recurrence.

Conclusion: Intrapulmonary SFT has a broad morphological spectrum with frequent epithelial entrapment as a key diagnostic pitfall. STAT6 is a reliable diagnostic marker, while ER < PR is common but of uncertain significance.

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肺内孤立性纤维性肿瘤29例临床病理分析，重点分析肺内孤立性纤维性肿瘤的形态谱和免疫组织化学特征。

背景：肺内孤立性纤维瘤（SFT）是一种罕见的间充质肿瘤，当呼吸上皮被包裹时，它可以模拟肺腺纤维瘤（PAF）。方法：我们回顾性分析了29例肺内SFTs，回顾了临床、组织病理学和免疫组织化学特征。评估STAT6、CD34、ER和PR。结果：该队列男性18人，女性11人，平均年龄55.3岁；69.0%无症状。肿瘤平均大小4.11 cm， 62.1%有胸膜附着。组织学上，79.3%表现为双相细胞，86.2%表现为鹿角血管，44.8%表现为上皮包裹。基质改变包括胶原化（89.7%）、出血（24.1%）、黏液样改变（20.7%）、囊性改变（6.9%）和多核巨细胞（3.4%）。风险分层确定25例低危，3例中危，1例高危。所有检测病例中STAT6阳性（28/28,100%），CD34阳性（96.3%）。结论：肺内SFT具有广泛的形态学特征，常出现上皮细胞夹闭是诊断的关键缺陷。STAT6是可靠的诊断标志物，而ER

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来源期刊

Diagnostic Pathology 医学-病理学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).