Modulation of optical properties of adipose tissue in diabetes mellitus associated with its glycation and hydration

IF 1.8 3区物理与天体物理 Q3 OPTICS

Applied Physics B Pub Date : 2026-07-03 DOI:10.1007/s00340-026-08700-6

Irina Yanina, Kirill Berezin, Daria Tuchina, Natalia Shushunova, Elena Stepanovich, Alla Bucharskaya, Artyom Mylnikov, Nikita Navolokin, Valery Tuchin

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引用次数: 0

Abstract

Diabetes mellitus (DM) is a group of metabolic diseases characterized by chronic hyperglycemia, which develops due to insulin resistance (T2DM), insulin deficiency, or glucagon overproduction (T1DM). One of the key consequences of hyperglycemia is nonenzymatic glycation of biomolecules, including proteins, lipoproteins, and lipids. The aim of this study was to determine the optical properties of adipose tissue in healthy rats and rats with experimentally induced T1DM using multiwavelength refractometry and spectroscopy, followed by data verification through histological analysis and molecular modeling. Glycation of collagen and phosphatidylethanolamine was shown to lead to expansion and destabilization of their hydration shells. A comprehensive analysis revealed a correlation between optical properties, structural changes in tissues, and their hydration. The differences in the optical properties of abdominal fat, arising from pathological glycation and hydration, could enable the development of label-free optical methods to monitor T1DM in experimental settings. This approach may ultimately support new strategies for predicting, diagnosing, and tracking the progression of T1DM in humans.

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糖尿病中与糖基化和水合作用相关的脂肪组织光学特性的调节

糖尿病（DM）是一组以慢性高血糖为特征的代谢性疾病，它是由胰岛素抵抗（T2DM）、胰岛素缺乏或胰高血糖素过量（T1DM）引起的。高血糖的主要后果之一是生物分子的非酶糖基化，包括蛋白质、脂蛋白和脂质。本研究的目的是利用多波长折射法和光谱学方法测定健康大鼠和实验性T1DM大鼠脂肪组织的光学特性，并通过组织学分析和分子模型验证数据。胶原蛋白和磷脂酰乙醇胺的糖基化被证明会导致其水合壳的膨胀和不稳定。综合分析揭示了光学性质、组织结构变化及其水合作用之间的相关性。由于病理性糖基化和水化引起的腹部脂肪光学特性的差异，可以在实验环境中开发无标记光学方法来监测T1DM。这种方法可能最终支持预测、诊断和跟踪人类T1DM进展的新策略。

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来源期刊

Applied Physics B 物理-光学

CiteScore

4.00

自引率

4.80%

发文量

202

审稿时长

3.0 months

期刊介绍： Features publication of experimental and theoretical investigations in applied physics Offers invited reviews in addition to regular papers Coverage includes laser physics, linear and nonlinear optics, ultrafast phenomena, photonic devices, optical and laser materials, quantum optics, laser spectroscopy of atoms, molecules and clusters, and more 94% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again Publishing essential research results in two of the most important areas of applied physics, both Applied Physics sections figure among the top most cited journals in this field. In addition to regular papers Applied Physics B: Lasers and Optics features invited reviews. Fields of topical interest are covered by feature issues. The journal also includes a rapid communication section for the speedy publication of important and particularly interesting results.