Verónica Puertas Martín, Sara LLamas-Velasco, Marta González-Sánchez, Víctor Blanco Palmero, Alberto García Redondo, David Pérez Martínez, Alberto Villarejo
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引用次数: 0
Abstract
Introduction: Frontotemporal dementia (FTD) comprises a heterogeneous group of neurodegenerative syndromes characterized by diverse behavioural, cognitive, and language profiles. Longitudinal data describing its clinical course progression using FTD-specific instruments remain limited. This study aimed to characterize the functional, cognitive, and behavioural trajectories of FTD clinical syndromes in a Spanish cohort, including assessments performed remotely during the COVID-19 pandemic.
Methods: Sixty-seven patients diagnosed with behavioural variant FTD (bvFTD), non-fluent variant primary progressive aphasia, or semantic variant PPA (svPPA) were prospectively followed at Hospital Universitario 12 de Octubre (Madrid, Spain). Functional and neuropsychiatric status were assessed with the Frontotemporal Dementia Rating Scale (FTD-FRS), the Interview for Deterioration in Daily Activities in Dementia (IDDD), the Neuropsychiatric Inventory (NPI), and the telephone Mini-Mental State Examination (t-MMSE). Thirty-three assessments were conducted remotely during pandemic restrictions.
Results: Over a mean follow-up of 3.1 years, significant declines were observed in FTD-FRS, IDDD, and t-MMSE (p < 0.001), whereas NPI scores remained stable. The svPPA group exhibited the greatest cognitive and functional decline, while bvFTD showed more heterogeneous progression. Twelve participants (18%) died during follow-up, predominantly older men with poorer baseline performance.
Conclusion: Functional and cognitive decline in FTD varies across clinical variants, with the semantic subtype showing the most rapid progression in our cohort. Remote assessments are feasible and represent a valid approach for longitudinal monitoring.
期刊介绍：
As a unique forum devoted exclusively to the study of cognitive dysfunction, ''Dementia and Geriatric Cognitive Disorders'' concentrates on Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field.
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