Flow rate dependence of salbutamol dose with various valved holding chambers in vitro.

IF 3.1 3区医学 Q2 RESPIRATORY SYSTEM

BMC Pulmonary Medicine Pub Date : 2026-07-01 DOI:10.1186/s12890-026-04456-z

Ville Vartiainen, Lauri Lehtimäki, Mikael Csonka, Péter Csonka

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引用次数: 0

Abstract

Background: Inhalation is the primary administration route for managing airway diseases like asthma and COPD. Presently, treatment protocols for management of acute obstruction in emergency care involve using either pressurized metered dose inhalers (pMDI), often with holding chambers (HC), or nebulizers. The aim of this work was to assess the impact of different inhalation patterns and specifically peak inspiratory flow rate (PIF) on drug delivery, as well as to provide a head-to-head comparison between different (HC) in combination with a salbutamol pMDI.

Methods: For the comparison we chose two reusable (Vortex and OptiChamber Diamond) and two disposable (DispoZABLE and LiteAire) HCs. The HCs were connected to an anatomical throat model, Next Generation Impactor, and breathing simulator and the deposited drug content was measured with high performance liquid chromatography. In the used inhalation patterns the PIFs were 15 l/min, 30 l/min, 60 l/min, and 80 l/min.

Results: All HCs decreased throat deposition by at least 80%, but throat deposition increased with higher PIF. There was some flow-dependency also in fine particle dose (FPD) but the direction of the dependency varied between the HCs.

Conclusions: The performance of disposable devices in terms of flow dependency and throat deposition was similar to reusable ones.

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沙丁胺醇剂量在不同带阀保持室的体外流速依赖性。

背景：吸入是治疗哮喘和慢性阻塞性肺病等气道疾病的主要给药途径。目前，急诊治疗急性梗阻的治疗方案包括使用加压计量吸入器（pMDI），通常带有保持室（HC），或雾化器。这项工作的目的是评估不同的吸入方式，特别是峰值吸入流量（PIF）对药物输送的影响，以及提供不同（HC）与沙丁胺醇pMDI组合之间的头对头比较。方法：选择两种可重复使用的（Vortex和OptiChamber Diamond）和两种一次性的（disposable和LiteAire） hc进行比较。将hc与解剖喉部模型、下一代冲击器和呼吸模拟器连接，用高效液相色谱法测定沉积的药物含量。在吸入模式下，pif分别为15 l/min、30 l/min、60 l/min和80 l/min。结果：所有hcc均可使喉部沉积减少至少80%，但喉部沉积随PIF升高而增加。细颗粒剂量（FPD）也存在一定的流量依赖性，但依赖方向在不同的hc之间有所不同。结论：一次性器械与可重复使用器械在流量依赖性和喉道沉积方面性能相近。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pulmonary Medicine RESPIRATORY SYSTEM-

CiteScore

4.40

自引率

3.20%

发文量

423

审稿时长

6-12 weeks

期刊介绍： BMC Pulmonary Medicine is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.