Auditory Efferent System Influencing the Auditory Overshoot Phenomenon: An Auditory Brainstem Response Study in Guinea Pigs.

IF 1.1 Q4 NEUROSCIENCES

Basic and Clinical Neuroscience Pub Date : 2025-03-01 DOI:10.32598/bcn.16.2.1939.1

Hassan Haddadzade Niri, Nariman Rahbar, Akram Pourbakht, Hamid Haghani

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Abstract

Introduction: Detection of a brief tonal signal at the beginning of a longer masking noise is difficult, but it becomes easier when the onset of the signal is delayed. This phenomenon is known as overshoot or temporal effect. Our study investigates the impact of the auditory efferent nerves (AENs) function on the auditory electrophysiological overshoot, further introducing an objective tool examining one of the AENs performances. Therefore, the effect and the trend of changes induced by low- and high-frequency stimuli on electrophysiological overshoot were studied in different delay onset times (DOTs) between the signal and the noise before and after dissecting the AENs.

Methods: Right internal auditory canals were exposed in 16 young male guinea pigs weighing 250 to 350 g. The inferior and posterior vestibular nerves known to carry AENs were transected in half of the subjects. Then, the ABR waveforms were recorded at 16 and 8 kHz tone burst stimuli at 0, 30, 60, and 100 ms DOTs relative to wideband noise. The latency values of auditory brainstem response (ABR) waves I and III were compared among the different DOTs and 5 signal-to-noise ratios (SNRs) before and after the surgery.

Results: By increasing DOTs, ABR waves I and III latency decreased in the control group before and after the surgery and in the case group before surgery at 16 kHz. However, the observed overshoot-like effect disappeared after the surgery in the case group. The wave's latency I and III increased from 0 to 30 ms, remained approximately constant from 30 to 60 ms, and then decreased toward 100 ms DOTs. However, none of the measurements at 8 kHz before and after surgery in both groups showed an overshoot effect.

Conclusion: Using the ABR paradigm, the overshoot phenomenon disappeared after the transection of AENs. The results confirmed the role of the efferent system in auditory overshooting. Therefore, an objective tool to measure auditory efferent function is provided.

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听觉传出系统影响听觉超调现象：豚鼠听觉脑干反应研究。

在一个较长的掩蔽噪声开始时检测一个简短的音调信号是困难的，但是当信号的开始被延迟时就变得容易了。这种现象被称为超调或时间效应。本研究探讨了听觉传出神经（AENs）功能对听觉电生理超调的影响，并进一步介绍了一种客观的工具来检测AENs的一种表现。因此，在解剖AENs前后不同的信号与噪声延时时间（DOTs）下，研究了低频和高频刺激对电生理超调的影响及其变化趋势。方法：16只体重250 ~ 350 g的年轻雄性豚鼠右内耳道外露。已知携带AENs的下前庭神经和后前庭神经在一半的受试者中被横断。然后，在相对于宽带噪声的0、30、60和100 ms DOTs下，记录16和8 kHz音调突发刺激下的ABR波形。比较不同DOTs和5个信噪比（SNRs）术前、术后听觉脑干反应（ABR） I、III波的潜伏期值。结果：通过增加DOTs，对照组手术前后和病例组手术前16 kHz ABR波I、III潜伏期降低。然而，在病例组中，观察到的超调效应在手术后消失。波的潜伏期I和III从0到30 ms增加，从30到60 ms大致保持不变，然后向100 ms DOTs下降。然而，两组手术前后8 kHz的测量结果均未显示出超调效应。结论：采用ABR范式，AENs横断后超调现象消失。结果证实了传出系统在听觉超调中的作用。因此，为测量听觉传出功能提供了一种客观的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Basic and Clinical Neuroscience NEUROSCIENCES-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.