{"title":"Mitochondrial Toxicity by 3-NP Enhanced Susceptibility to Defective Social Behaviors in Male Wistar Rats.","authors":"Fatemeh Nasehi, Fariba Khodagholi, Neda Kaveh, Ali Maleki, Arman Zeinaddini-Meymand, Maryam Alsadat Mousavi, Dariush Minai-Tehrani, Forough Foolad","doi":"10.32598/bcn.2024.6604.1","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The impaired mitochondrial function in neurons is a principal abnormality in many medical conditions. Behavioral changes are the key aspects that emerge under these conditions. In the current study, we investigated whether social interactions are influenced by 3-nitropropionic acid (3-NP)-induced mitochondrial failure. We also assessed changes in glucocorticoid receptor (GR) and FKBP5 protein levels, cytochrome contents, and monoamine oxidase (MAO) A and B activities in the striatum (ST), hippocampus (HIP), and prefrontal cortex (PFC) of the subjects.</p><p><strong>Methods: </strong>Adult male Wistar rats were treated with 3-NP. Then, the social and non-social behaviors of 3-NP-treated rats were investigated. Different dissected brain regions were considered regarding GR and FKBP5 protein levels, cytochrome contents, and MAO-A and MAO-B.</p><p><strong>Results: </strong>We found a significantly decreased duration of social behaviors and impaired non-social behavioral tests. We detected a decreasing trend in GR and FKBP5 protein levels. Moreover, cytochrome contents and MAO A and B activities decreased in the dissected brain regions.</p><p><strong>Conclusion: </strong>Impaired social/non-social behaviors and decreased levels of investigated molecular variables in the regions mentioned above after 3-NP treatment might point to processes connecting mitochondrial failure to behavioral impairment, particularly social type.</p>","PeriodicalId":8701,"journal":{"name":"Basic and Clinical Neuroscience","volume":"16 2","pages":"489-504"},"PeriodicalIF":1.1000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318196/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Basic and Clinical Neuroscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32598/bcn.2024.6604.1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: The impaired mitochondrial function in neurons is a principal abnormality in many medical conditions. Behavioral changes are the key aspects that emerge under these conditions. In the current study, we investigated whether social interactions are influenced by 3-nitropropionic acid (3-NP)-induced mitochondrial failure. We also assessed changes in glucocorticoid receptor (GR) and FKBP5 protein levels, cytochrome contents, and monoamine oxidase (MAO) A and B activities in the striatum (ST), hippocampus (HIP), and prefrontal cortex (PFC) of the subjects.
Methods: Adult male Wistar rats were treated with 3-NP. Then, the social and non-social behaviors of 3-NP-treated rats were investigated. Different dissected brain regions were considered regarding GR and FKBP5 protein levels, cytochrome contents, and MAO-A and MAO-B.
Results: We found a significantly decreased duration of social behaviors and impaired non-social behavioral tests. We detected a decreasing trend in GR and FKBP5 protein levels. Moreover, cytochrome contents and MAO A and B activities decreased in the dissected brain regions.
Conclusion: Impaired social/non-social behaviors and decreased levels of investigated molecular variables in the regions mentioned above after 3-NP treatment might point to processes connecting mitochondrial failure to behavioral impairment, particularly social type.
期刊介绍：
BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.
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