Cytological Features of CIC-Rearranged Sarcoma: A Report of 5 New Cases and Review of the Literature.

IF 1.5 4区医学 Q3 PATHOLOGY

Acta Cytologica Pub Date : 2026-06-30 DOI:10.1159/000553217

Pawel Gajdzis, Jerzy Klijanienko

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引用次数: 0

Abstract

Introduction: CIC-rearranged sarcoma is a rare, Ewing-like round cell sarcoma and is poorly described in the cytology literature, with only seven cases reported to date.

Methods: This report presents five new cases investigated and treated at the Institut Curie (four tumours showed CIC-DUX4 and one showed CIC-NUTM1 fusions) and reviews corresponding cytological literature.

Results: Smears were cellular in all cases. They comprised of isolated and clustered round, oval, and short spindle cells, with rosettes in three cases. Cytoplasm varied in volume and occasionally showed microvacuolation. Marked pleomorphism and rhabdoid features were detected in one CIC-NUTM1 sarcoma and in one CIC-DUX4 sarcoma. CD99 was positive in three cases and negative in two. Original cytologic diagnoses included two round cell sarcomas (one with myxoid features), pleomorphic sarcoma with rhabdoid features, Ewing sarcoma, and rhabdomyosarcoma.

Conclusion: Fine-needle aspiration appears to be at least as effective as core-needle biopsy for these malignancies. Cytomorphological features, together with the immunohistochemical profile and detection of CIC rearrangements, can help accurately diagnose this rare malignancy.

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cic重排肉瘤的细胞学特征。5例新病例报告及文献复习。

CIC重排肉瘤是一种罕见的尤文氏样圆形细胞肉瘤，在细胞学文献中描述较少，迄今为止仅报道了7例。本报告介绍了居里研究所调查和治疗的5例新病例（4例肿瘤显示CIC - DUX4, 1例显示CIC - NUTM1融合），并回顾了相应的细胞学文献。所有病例的涂片均为细胞性。它们由孤立和聚集的圆形、椭圆形和短纺锤体细胞组成，其中三种情况下有莲座。细胞质体积变化，偶见微液泡形成。1例CIC-NUTM1肉瘤和1例CIC-DUX4肉瘤均有明显的多形性和横纹肌样特征。CD99阳性3例，阴性2例。最初的细胞学诊断包括两个圆形细胞肉瘤（一个具有黏液样特征），具有横纹肌样特征的多形性肉瘤，尤文氏肉瘤和横纹肌肉瘤。对于这些恶性肿瘤，细针穿刺似乎至少与核心针活检一样有效。细胞形态学特征，结合免疫组织化学特征和CIC重排检测，可以帮助准确诊断这种罕见的恶性肿瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Cytologica 生物-病理学

CiteScore

3.70

自引率

11.10%

发文量

审稿时长

4-8 weeks

期刊介绍： With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.