Management of central corneal opacities using manual and femtosecond laser–assisted rotational anterior lamellar autokeratoplasty: A descriptive case series

J.A. Gegúndez-Fernández, B. Burgos-Blasco, M. Ariño-Gutiérrez, P. Pérez-García, M. Molero-Senosiain, D. Díaz-Valle
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Abstract

Background and objective

To describe the outcomes of rotational anterior lamellar autokeratoplasty (RALK) in central corneal opacities, assessing changes in visual acuity, astigmatism, and central corneal densitometry.

Patients and methods

Retrospective descriptive case series of 9 eyes with central opacities and at least 4 mm of clear peripheral cornea, treated with manual RALK or femtosecond laser-assisted RALK. Demographic and clinical variables, leucoma characteristics, surgical parameters and postoperative evolution of best-corrected distance visual acuity (BCDVA), astigmatism, and central corneal densitometry (CCD) were analyzed. Pre- and postoperative values were compared, with statistical significance set at p < 0.05.

Results

Mean age was 44.9 years (5 women, 4 men) with a mean interval to surgery of 19.8 months. Mean leucoma area was 9.73 mm², with a depth of 268.4 μm and corneal thickness of 426.3 μm. Lamellar cut depth was 280.9 μm and graft diameter 7.9 mm. Median number of sutures was 4 (range 3–16). In 5 cases, the opacity was displaced to the superior cornea. BCDVA improved from 0.17 to 0.57 (decimal scale) at one year (p = 0.008). Astigmatism decreased from 7.7 to 5.9 D (p = 0.425), and CCD from 61.1% to 25.0% (p = 0.008). Mean follow-up was 2.4 years. One herpetic recurrence and two additional surgical procedures were recorded.

Conclusions

RALK is an effective and safe technique for relocating central corneal opacities outside the visual axis and improving visual function in selected patients. Femtosecond laser assistance provides greater precision and edge congruency, which may facilitate earlier suture removal.
使用手动和飞秒激光辅助旋转前板层自体角膜移植术治疗中央性角膜混浊:描述性病例系列。
背景和目的:描述旋转前板层自体角膜移植术(RALK)治疗中央性角膜混浊的结果,评估视力、散光和中央性角膜密度的变化。患者和方法:回顾性描述性病例系列,9只眼,中央混浊,周围角膜透明至少4mm,采用手动RALK或飞秒激光辅助RALK治疗。分析人口统计学和临床变量、白斑特征、手术参数和术后最佳矫正距离视力(BCDVA)、散光和角膜中央密度(CCD)的变化。结果:平均年龄44.9岁(女5例,男4例),平均手术间隔19.8个月。平均白斑面积9.73 mm²,深度268.4 μm,角膜厚度426.3 μm。片层切割深度280.9 μm,接枝直径7.9 mm。中位缝合线数为4(范围3-16)。5例角膜混浊移位至上角膜。BCDVA在一年后从0.17改善到0.57(十进制)(p = 0.008)。散光从7.7 D降至5.9 D (p = 0.425), CCD从61.1%降至25.0% (p = 0.008)。平均随访时间为2.4年。记录了一例疱疹复发和两次额外的外科手术。结论:RALK是一种安全有效的角膜中央混浊物视觉轴外移位技术,可改善部分患者的视功能。飞秒激光辅助提供更高的精度和边缘一致性,可能有助于早期拆除缝线。
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