Biological and social rhythm differences, daily melatonin secretion and psychiatric symptoms in healthy adults.

IF 2.3 4区医学 Q2 PSYCHIATRY

International Journal of Psychiatry in Clinical Practice Pub Date : 2026-06-29 DOI:10.1080/13651501.2026.2695468

Ümran Eğilmez, Fatih Ekici, Ali Kandeğer, Yavuz Selvi

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引用次数: 0

Abstract

Objective: To examine associations of chronotype and social jetlag (SJL) with psychiatric symptoms and melatonin secretion in healthy adults.

Methods: In this cross-sectional study, 95 relatively young, university-affiliated students and staff completed the MEQ, SCL-90-R, MCTQ and a one-week sleep diary. SJL was defined as the workday-free-day difference in midsleep. Overnight workday urinary 6-sulfatoxymelatonin (6-SMT) was assayed by ELISA and indexed to creatinine.

Results: Evening chronotypes had longer SJL than intermediate and morning chronotypes (F = 16.70, p < .001). Higher MEQ scores were associated with shorter SJL and earlier midsleep (r = -0.54 to -0.66, all p < .001). Total SCL-90-R scores did not differ across chronotypes (p = .367), whereas obsessive-compulsive symptoms were higher in the evening group (p = .027). Urinary 6-SMT/creatinine did not differ by chronotype (F = 0.823, p = .442) or relate to SJL; BMI correlated inversely with 6-SMT (r = -0.21, p = .043). Lower MEQ scores independently predicted longer SJL (B = -2.82, β = -0.54, p < .001).

Conclusions: Eveningness was associated with greater SJL and obsessive-compulsive symptoms, whereas overnight 6-SMT was not linked to chronotype or SJL. The inverse BMI-6-SMT association may suggest metabolic relevance.

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健康成人的生理和社会节律差异、每日褪黑素分泌和精神症状

目的：探讨健康成人睡眠类型和社交时差（SJL）与精神症状和褪黑激素分泌的关系。方法：在本横断面研究中，95名相对年轻的大学附属学生和教职员完成了MEQ、SCL-90-R、MCTQ和一周睡眠日记。SJL定义为工作日-自由日的睡眠差异。采用ELISA法检测夜间尿6-亚砜氧褪黑素（6-SMT）水平，并与肌酐指标进行比较。结果：晚睡者的SJL较中早睡者长（F = 16.70, p r = -0.54 ~ -0.66， p p均= .367），而晚睡者的强迫症状较高（p = .027）。尿6-SMT/肌酐与时间型无差异（F = 0.823, p = 0.442），与SJL无关；BMI与6-SMT呈负相关（r = -0.21, p = 0.043）。较低的MEQ评分独立预测较长的SJL （B = -2.82, β = -0.54, p）。结论：晚上性与较高的SJL和强迫症状相关，而过夜6-SMT与时间型或SJL无关。BMI-6-SMT负相关可能提示代谢相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Psychiatry in Clinical Practice 医学-精神病学

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

>12 weeks

期刊介绍： International Journal of Psychiatry in Clinical Practice provides an international forum for communication among health professionals with clinical, academic and research interests in psychiatry. The journal gives particular emphasis to papers that integrate the findings of academic research into realities of clinical practice. Focus on the practical aspects of managing and treating patients. Essential reading for the busy psychiatrist, trainee and interested physician. Includes original research papers, comprehensive review articles and short communications. Key words: Psychiatry, Neuropsychopharmacology, Mental health, Neuropsychiatry, Clinical Neurophysiology, Psychophysiology, Psychotherapy, Addiction, Schizophrenia, Depression, Bipolar Disorders and Anxiety.