Ancestry Matters in Decoding Immunity

IF 3.3 4区医学 Q3 CELL BIOLOGY

Immunology & Cell Biology Pub Date : 2026-08-04 Epub Date: 2026-06-30 DOI:10.1111/imcb.70143

Kesong Wu, Amanda J. Oliver, Zewen Kelvin Tuong

引用次数: 0

Abstract

The Chinese Immune Multi-Omics Atlas (CIMA) establishes a population-scale immune multi-omics atlas by profiling over 10 million peripheral blood mononuclear cells from 428 Chinese adults using paired scRNA-seq and scATAC-seq. This resource mitigates longstanding European ancestry bias in single-cell genomics and enables cell type resolved regulatory mapping across immune populations. Building on this atlas, CIMA-CLM integrates chromatin sequence features with single-cell transcriptomic context to predict chromatin accessibility and assess noncoding variant effects, exemplified in FOXP3⁺ regulatory T cells.

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祖先在免疫解码中的作用

中国免疫多组学图谱（CIMA）通过使用配对scRNA-seq和scATAC-seq对来自428名中国成年人的1000多万个外周血单个核细胞进行分析，建立了一个人群规模的免疫多组学图谱。该资源减轻了单细胞基因组学中长期存在的欧洲血统偏见，并使跨免疫人群的细胞类型解决调节映射成为可能。在此图谱的基础上，CIMA-CLM将染色质序列特征与单细胞转录组学背景相结合，以预测染色质可及性并评估非编码变异效应，例如FOXP3+调节性T细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology & Cell Biology 医学-免疫学

CiteScore

7.50

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.