Tau Accumulation and Dopamine Transporter Availability in Elderly Adults with Depression.

IF 1.8 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Nippon Medical School Pub Date : 2026-01-01 DOI:10.1272/jnms.JNMS.2026_93-308

Shotaro Uchiyama, Ryosuke Arakawa, Takeshi Sakayori, Tsuyoshi Nogami, Tomoyuki Ohya, Makoto Higuchi, Amane Tateno

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引用次数: 0

Abstract

Background: Depression in later life is associated with dopaminergic dysfunction and increased risk of neurodegenerative disorders, although the relationship between dopamine transporter (DAT) availability and tau accumulation remains unclear. Although previous studies have linked tau and DAT in neurodegenerative diseases, evidence related to depression is limited. Therefore, this study used positron emission tomography (PET) to investigate the association between tau pathology and DAT availability in elderly adults with depression.

Methods: Six patients diagnosed with depression according to ICD-10 criteria underwent PET scans with PET radioligands that enable accurate in vivo assessment, namely, florzolotau (18F) for tau and [¹⁸F]FE-PE2I for DAT. Clinical assessments using the Mini-Mental State Examination (MMSE) and Hamilton Depression Rating Scale (HAM-D) were performed for all patients. Tau standardized uptake value ratios (SUVR) in the striatal and cortical regions and DAT binding potentials (BP_ND) in the striatum were calculated.

Results: Tau SUVR in all regions was negatively correlated with DAT BP_ND in the striatum, suggesting that greater tau burden may be linked to dopaminergic dysfunction. Tau SUVR in the striatum was negatively correlated with MMSE, indicating that tau accumulation may be related to subtle cognitive decline. DAT BP_ND in the striatum was not correlated with HAM-D.

Conclusions: These preliminary results suggest a link between tau pathology and dopaminergic dysfunction in elderly adults with depression.

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老年抑郁症患者Tau蛋白积累和多巴胺转运体有效性。

背景：晚年抑郁与多巴胺能功能障碍和神经退行性疾病风险增加有关，尽管多巴胺转运体（DAT）可用性与tau积累之间的关系尚不清楚。虽然以前的研究已经将tau和DAT与神经退行性疾病联系起来，但与抑郁症相关的证据有限。因此，本研究使用正电子发射断层扫描（PET）来研究老年抑郁症患者tau病理与DAT可用性之间的关系。方法：6例根据ICD-10标准诊断为抑郁症的患者接受PET扫描，PET放射配体能够准确地在体评估，即tau为florzolotau (18F)， DAT为FE-PE2I [18F]。采用简易精神状态检查（MMSE）和汉密尔顿抑郁评定量表（HAM-D）对所有患者进行临床评估。计算纹状体和皮质区的Tau标准化摄取值比（SUVR）和纹状体的DAT结合电位（BPND）。结果：所有区域的Tau SUVR与纹状体的DAT BPND呈负相关，表明较大的Tau负担可能与多巴胺能功能障碍有关。纹状体中Tau SUVR与MMSE呈负相关，表明Tau积累可能与微妙的认知能力下降有关。纹状体DAT BPND与HAM-D无相关性。结论：这些初步结果表明，老年抑郁症患者的tau蛋白病理与多巴胺能功能障碍之间存在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nippon Medical School MEDICINE, GENERAL & INTERNAL-

CiteScore

1.80

自引率

10.00%

发文量

118

期刊介绍： The international effort to understand, treat and control disease involve clinicians and researchers from many medical and biological science disciplines. The Journal of Nippon Medical School (JNMS) is the official journal of the Medical Association of Nippon Medical School and is dedicated to furthering international exchange of medical science experience and opinion. It provides an international forum for researchers in the fields of bascic and clinical medicine to introduce, discuss and exchange thier novel achievements in biomedical science and a platform for the worldwide dissemination and steering of biomedical knowledge for the benefit of human health and welfare. Properly reasoned discussions disciplined by appropriate references to existing bodies of knowledge or aimed at motivating the creation of such knowledge is the aim of the journal.