Low Serum Alkaline Phosphatase Levels in Paediatric sepsis Correlate With Acute Kidney Injury: A Multicenter Retrospective Study.

IF 1.8 4区医学 Q1 PEDIATRICS

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-06-28 DOI:10.1111/apa.70665

Evgenia Gurevich, Ido Levi, Yehonatan Marziano, Michael Kalinin, Natalya Bilenko, Daniel Landau

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引用次数: 0

Abstract

Aims: To investigate the association between serum ALP levels and the development of AKI in paediatric patients with sepsis.

Methods: Retrospective screening of a computerized database of 4 Israeli regional hospitals for children (0-18 years) hospitalized between 1.01.2000-1.06.2024 with ICD-9 sepsis-related diagnoses (study group) and age- and sex-matched non-septic febrile patients (controls). Serum ALP levels were sex- and age-adjusted and described as standard deviation scores (SDS).

Results: Of 809 952 screened hospitalizations, 701 records comprised the study group. Their median (IQR) age was 17 (10-38) months, 53% were males. Nadir ALP-SDS was lower in the sepsis group compared to controls (-1.65 ± 1.11 vs. -0.97 ± 1.36, p < 0.001) and further lower in those with AKI, which occurred in 23% of the sepsis cohort (-1.95 ± 1.16 vs. -1.56 ± 1.09, p < 0.001). Hospital stay was longer in the AKI compared to non-AKI group [median (IQR): 7 (4, 12) vs. 4 (3, 5) days, p < 0.001]. Lower ALP-SDS was independently associated with AKI [OR (95% CI): 0.7 (0.6-0.8), p < 0.001], after controlling for CRP and leucocyte count.

Conclusions: ALP was lower in sepsis patients compared to controls, and significantly lower in AKI vs. non-AKI group, suggesting it as an additional marker of infection severity.

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儿童脓毒症低血清碱性磷酸酶水平与急性肾损伤相关：一项多中心回顾性研究。

目的：探讨儿童脓毒症患者血清ALP水平与AKI发生的关系。方法：回顾性筛选以色列4家地区医院计算机数据库中2000年1月1日至2024年1月1日期间诊断为ICD-9败血症相关的住院儿童（0-18岁）（研究组）和年龄和性别匹配的非败血症发热患者（对照组）。血清ALP水平经性别和年龄调整，用标准差评分（SDS）描述。结果：在809952例经筛选的住院病例中，有701例记录构成了研究组。中位（IQR）年龄为17（10-38）个月，男性占53%。脓毒症组的Nadir ALP- sds低于对照组（-1.65±1.11 vs -0.97±1.36,p）。结论：脓毒症患者的ALP低于对照组，AKI组的ALP明显低于非AKI组，提示其是感染严重程度的另一个标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries