Pancreatic Cytology Precision: A Comparative Lens on Papanicolaou Society of Cytopathology and World Health Organization Reporting System.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Journal of Cytology Pub Date : 2026-04-01 Epub Date: 2026-05-16 DOI:10.4103/joc.joc_103_25

Ojas Gupta, Ram Nawal Rao, Rahul Kumar Gupta, Asmita Arya, Sushma Agrawal, Praveer Rai, Ashok Kumar

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引用次数: 0

Abstract

Context: Pancreatic lesions range from benign cystic to premalignant and frankly malignant. The Papanicolaou Society of Cytopathology (PSC) was established in 2014 for pancreaticobiliary cytology, with a six-tiered system. Recently, the World Health Organization (WHO) proposed a reporting system for pancreaticobiliary cytopathology.

Aims: This study aimed to apply PSC and WHO systems to pancreatic cytology samples and compare their risk assessment.

Materials and methods: The Institutional Hospital Information System was searched for all pancreatic endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), transabdominal ultrasound-guided FNA (TUS-FNA), and pancreatic fluid cytology samples from January 2016 to April 2025, and cases were reassigned as per the PSC and WHO diagnostic categories by two cytopathologists. Risk of malignancy (ROM) in each diagnostic category was assessed using available histopathological, clinical, radiological, biochemical, and follow-up data.

Results: Of 281 pancreatic cytology cases via EUS (64.1%) and TUS-FNA (35.9%), 197 had complete follow-up records. The ROM for the PSC categories I-VI was 58.3%, 0%, 75%, 64.7%, 100%, and 100%. For WHO system categories I-IV, VI-VII, ROM values were 66.7%, 0%, 75%, 0%, 100%, and 100%. These findings indicate that the WHO system offers more effective risk stratification. Furthermore, compared with the PSC system, the WHO system showed an increase in sensitivity (89.2% vs. 81.4%), negative predictive value (NPV; 82.7% vs. 73.9%), and accuracy (92.9% vs. 87.8%), while specificity and positive predictive value (PPV) stayed consistent at 100%.

Conclusion: The WHO reporting system for pancreatic cytology offers superior risk categorization, sensitivity, NPV, and accuracy compared with the PSC system, while maintaining comparable specificity and PPV.

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胰腺细胞学精度：帕帕尼柯拉氏细胞病理学学会与世界卫生组织报告系统的比较镜头。

背景：胰腺病变范围从良性囊性到癌前病变和恶性病变。Papanicolaou细胞病理学学会（PSC）成立于2014年，用于胰胆管细胞学，具有六层系统。最近，世界卫生组织（WHO）提出了胰胆管细胞病理学报告制度。目的：本研究旨在将PSC和WHO系统应用于胰腺细胞学样本，并比较它们的风险评估。材料与方法：检索机构医院信息系统中2016年1月至2025年4月所有超声内镜引导下的胰腺细针穿刺（EUS-FNA）、经腹超声引导下的胰腺细针穿刺（TUS-FNA）和胰液细胞学样本，由2名细胞病理学家根据PSC和WHO诊断分类重新分配病例。利用现有的组织病理学、临床、放射学、生化和随访数据评估每个诊断类别的恶性肿瘤（ROM）风险。结果：281例胰腺细胞学检查中，EUS和TUS-FNA分别占64.1%和35.9%，197例有完整的随访记录。PSC I-VI类的ROM分别为58.3%、0%、75%、64.7%、100%和100%。对于WHO系统I-IV、VI-VII类，ROM值分别为66.7%、0%、75%、0%、100%和100%。这些发现表明，世卫组织系统提供了更有效的风险分层。此外，与PSC系统相比，WHO系统在敏感性（89.2% vs. 81.4%）、阴性预测值（NPV; 82.7% vs. 73.9%）和准确性（92.9% vs. 87.8%）方面均有所提高，而特异性和阳性预测值（PPV）保持一致，均为100%。结论：与PSC系统相比，WHO胰腺细胞学报告系统提供了更好的风险分类、敏感性、NPV和准确性，同时保持了相当的特异性和PPV。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cytology MEDICAL LABORATORY TECHNOLOGY-

CiteScore

1.80

自引率

7.70%

发文量

审稿时长

46 weeks

期刊介绍： The Journal of Cytology is the official Quarterly publication of the Indian Academy of Cytologists. It is in the 25th year of publication in the year 2008. The journal covers all aspects of diagnostic cytology, including fine needle aspiration cytology, gynecological and non-gynecological cytology. Articles on ancillary techniques, like cytochemistry, immunocytochemistry, electron microscopy, molecular cytopathology, as applied to cytological material are also welcome. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed original research papers, case reports, systematic reviews, meta-analysis, and debates.