[Evaluation of the inflammatory response after implantation of different types of phakic intraocular lenses in high myopia].

Q3 Medicine

Vestnik oftalmologii Pub Date : 2026-01-01 DOI:10.17116/oftalma202614203138

Z S Kamalov, Kh M Kamilov, A F Yusupov, N N Zaynutdinov

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引用次数: 0

Abstract

High myopia is one of the main causes of reversible vision loss worldwide among the working-age population. Despite the widespread use of phakic intraocular lenses (PIOLs) for correction, immunological changes in the aqueous humor before and after implantation remain insufficiently studied.

Objective: The study aimed to assess and compare cytokine levels in the aqueous humor before and after implantation of collamer-based and acrylic-based PIOLs in patients with high myopia.

Material and methods: The study included 58 patients (103 eyes) with high myopia scheduled for PIOL implantation. The main group (A) consisted of 36 patients (68 eyes) who received collamer-based PIOLs. The comparison group (B) comprised 22 patients (35 eyes) who received acrylic-based PIOLs. The control group included 20 patients (20 eyes) with emmetropia. Cytokine levels of IL-6, TNF-α, and TGF-β2 were studied only in 18 patients (30 eyes) using solid-phase enzyme-linked immunosorbent assay with special reagents.

Results: After implantation of different types of PIOLs, all patients included in the study achieved the desired outcome: residual refractive error (0.75±0.5 D) and visual acuity (0.85±0.17) remained stable during the 24-month postoperative period. Before PIOL implantation, patients with high myopia showed a statistically significant increase in IL-6 concentration - more than 2.5-fold (9.51±0.52 pg/ml vs 3.82±0.26 pg/ml in the control group) (p<0.001). The TNF-α level increased almost 1.8-fold (9.98±0.53 pg/ml vs 5.63±0.42 pg/ml in the control group) (p<0.001). In the main group, the TGF-β2 level was 15.99±1.09 pg/ml, which was 4.1- times higher than the control values (3.88±0.26 pg/ml) (p<0.001).

Conclusion: PIOL implantation in high myopia is an effective, safe, and reliable correction method associated with marked changes in the local cytokine profile. Collamer lenses induce a less intense inflammatory response and a more active remodeling reaction compared with acrylic lenses.

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[高度近视不同类型晶状体人工晶体植入术后炎症反应的评价]。

高度近视是世界范围内劳动年龄人口可逆性视力丧失的主要原因之一。尽管有晶状体人工晶状体（PIOLs）被广泛用于矫正，但植入前后房水的免疫学变化仍未得到充分研究。目的：评价和比较高度近视患者角膜基和丙烯酸基人工晶状体植入术前后房水细胞因子水平。材料与方法：选择高度近视患者58例（103眼）行PIOL植入术。主组（A组）36例（68只眼）接受基于眼圈的PIOLs。对照组（B组）22例（35只眼）接受丙烯酸基piol治疗。对照组为斜视患者20例（20只眼）。采用专用试剂固相酶联免疫吸附法，仅对18例（30眼）患者IL-6、TNF-α、TGF-β2的细胞因子水平进行了研究。结果：不同类型piol植入术后，所有患者均达到预期效果：术后24个月，残余屈光不差（0.75±0.5 D）和视力（0.85±0.17）保持稳定。高度近视患者在PIOL植入前IL-6浓度升高有统计学意义，超过2.5倍（9.51±0.52 pg/ml vs对照组3.82±0.26 pg/ml） (pα水平升高近1.8倍（9.98±0.53 pg/ml vs对照组5.63±0.42 pg/ml） (pβ2水平为15.99±1.09 pg/ml，比对照组（3.88±0.26 pg/ml）高4.1倍(p结论：高度近视眼植入术是一种有效、安全、可靠的矫正方法，与局部细胞因子谱的显著变化有关。与丙烯酸镜片相比，Collamer镜片引起的炎症反应较弱，重塑反应更活跃。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vestnik oftalmologii Medicine-Ophthalmology

CiteScore

0.80

自引率

0.00%

发文量

129

期刊介绍： The journal publishes materials on the diagnosis and treatment of eye diseases, hygiene of vision, prevention of ophthalmic affections, history of Russian ophthalmology, organization of ophthalmological aid to the population, as well as the problems of special equipment. Original scientific articles and surveys on urgent problems of theory and practice of Russian and foreign ophthalmology are published. The journal contains book reviews on ophthalmology, information on the activities of ophthalmologists" scientific societies, chronicle of congresses and conferences.The journal is intended for ophthalmologists and scientific workers dealing with clinical problems of diseases of the eye and physiology of vision.