Predictive Value of the Lowest Serum Albumin Level During Hospitalization in Patients With Intracerebral Hemorrhage.

Abstract

Background and purpose: This study aimed to explore the potential association between the lowest serum albumin concentration during hospitalization and the prognosis of patients with intracerebral hemorrhage (ICH) in order to provide a scientific basis for selecting and optimizing clinical treatment options.

Methods: A total of 268 patients with ICH were retrospectively analyzed. The study outcome was 90-day mRS (mRS > 2). Univariate and multivariate analyses and ROC curve analyses were used to identify the correlation between the lowest serum albumin concentration and the prognosis of patients with ICH.

Results: (1) The lowest serum albumin concentration, Glasgow Coma Score (GCS), and hematoma volume were independent predictors of outcome in patients with ICH (p < 0.05). (2) A good outcome in patients with ICH was predicted when the lowest serum albumin levels were > 31.8 g/L (AUC = 0.849, 95% CI: 0.801-0.890, p < 0.001), the GCS was > 11 (AUC = 0.878, 95% CI: 0.833-0.915, p < 0.001), and the hematoma volume was ≤ 23.6 mL (AUC = 0.863, 95% CI: 0.815 to 0.902, p < 0.001). (3) The lowest serum albumin concentration was statistically different between GCS (3-8, 9-12, 13-15: 29.30 [3.90], 33.80 [6.85], 36.70 [5.55]) (χ ² = 69.696, p < 0.001) and had a positive correlation with GCS (r _s  = 0.569).

Conclusions: The lowest serum albumin concentration during hospitalization was an independent predictor of poor outcome in ICH, and when serum albumin was greater than 31.8 g/L, it predicted a good outcome. In addition, the degree of consciousness disturbance may have some influence on the serum albumin level, and the specific mechanism needs further study.