The ER-Resident Protein PDZD8 Inhibits Virus Production of West Nile Virus

IF 1.6 4区医学 Q4 IMMUNOLOGY

Microbiology and Immunology Pub Date : 2026-09-08 Epub Date: 2026-06-29 DOI:10.1111/1348-0421.70072

Shiori Abe, Akari Sato, Haruto Eguchi, Keisuke Maezono, Passawat Thammahakin, Duong Thi Ngoc Thuy, Hiroaki Kariwa, Shintaro Kobayashi

引用次数: 0

Abstract

West Nile virus (WNV) remodels the endoplasmic reticulum (ER) membrane in cells to aid virus production. However, the molecular mechanisms underlying this process remain unclear. PDZD8 is an ER-resident protein that mediates ER–mitochondria contact and lipid transfer, both of which are associated with membrane remodeling. In this study, we found that WNV infection suppressed the expression of PDZD8, leading to a reduction in ER–mitochondria contact sites. By contrast, PDZD8 suppressed WNV production by inhibiting the processes of viral particle assembly and release. These findings suggest that WNV suppresses PDZD8 expression to partially counteract its inhibitory effect on WNV production.

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内质网驻留蛋白PDZD8对西尼罗病毒产生的抑制作用

西尼罗河病毒（WNV）重塑细胞内的内质网（ER）膜，以帮助病毒的产生。然而，这一过程的分子机制尚不清楚。PDZD8是一种内质网驻留蛋白，介导内质网线粒体接触和脂质转移，这两者都与膜重塑有关。在这项研究中，我们发现西尼罗河病毒感染抑制了PDZD8的表达，导致er -线粒体接触位点减少。相比之下，PDZD8通过抑制病毒颗粒的组装和释放过程来抑制西尼罗河病毒的产生。这些发现表明，WNV通过抑制PDZD8的表达来部分抵消其对WNV产生的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiology and Immunology 医学-免疫学

CiteScore

5.20

自引率

3.80%

发文量

审稿时长

1 months

期刊介绍： Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.