Advancing Dimensional Models of Psychopathology in Cancer: Insights From Applying the Hierarchical Taxonomy of Psychopathology (HiTOP).

IF 3.9 2区医学 Q2 ONCOLOGY

Psycho‐Oncology Pub Date : 2026-07-01 DOI:10.1002/pon.70533

Darren Haywood, Jai Carmichael, Miriam K Forbes, Roman Kotov, Robert F Krueger, Aidan G C Wright, Susan L Rossell, David Castle, Wendy Lam, Maryam Lustberg, Colin E Vize, Anna Ugalde, Phyllis Butow, Nicolas H Hart

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引用次数: 0

Abstract

Objective: Cancer survivors, defined as those living with or beyond a cancer diagnosis, experience more than double the prevalence of psychopathology when compared to the general population. Categorical diagnostic systems, such as the Diagnostic and Statistical Manual of Mental Disorders (DSM), remain dominant in psycho-oncology despite concerns about reliability, validity, and clinical utility for this population. Dimensional frameworks, such as the Hierarchical Taxonomy of Psychopathology (HiTOP), offer a more precise alternative; however, they have not yet been widely applied in cancer survivors. Accordingly, the objective of this research was to examine the applicability of HiTOP to cancer survivors.

Methods: Data from 1389 participants in 28 countries (n = 728 cancer survivors; n = 661 community/psychiatric) were collected using the 405-item HiTOP-SR, alongside demographic, clinical, and cancer-specific measures. The HiTOP-SR normative sample (n = 780) was also used. Analyses included parametric, non-parametric, and factor analytic approaches.

Results: All HiTOP-SR scales demonstrated strong homogeneity and reliability in cancer survivors. Cancer survivors showed significant elevations across Internalising and Somatoform spectra, with current cancer associated with additional elevations in domains of Thought Disorder and components of Disinhibited and Antagonistic psychopathology. An 11-factor model was developed and supported for both cancer and community/psychiatric samples, though the magnitudes of the factor loadings sometimes varied between samples. External validity was strong with theoretically aligned associations.

Conclusion: The HiTOP-SR appears reliable within cancer survivors and provides utility in quantifying a broad array of psychopathology experienced. The results highlight the potential applicability and utility of HiTOP to improve cancer research and clinical practice in psycho-oncology.

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推进癌症精神病理学的维度模型：来自应用精神病理学层次分类法（HiTOP）的见解。

目的：癌症幸存者，定义为那些患有或超过癌症诊断的人，与一般人群相比，精神病理学的患病率超过两倍。分类诊断系统，如精神疾病诊断和统计手册（DSM），在精神肿瘤学中仍然占主导地位，尽管对这一人群的可靠性、有效性和临床实用性存在担忧。维度框架，如精神病理学层次分类法（HiTOP），提供了一个更精确的选择；然而，它们尚未广泛应用于癌症幸存者。因此，本研究的目的是检验HiTOP对癌症幸存者的适用性。方法：从28个国家的1389名参与者（n = 728名癌症幸存者；n = 661名社区/精神病患者）中收集数据，使用405项HiTOP-SR，以及人口统计学、临床和癌症特异性测量。采用HiTOP-SR标准样本（n = 780）。分析包括参数分析、非参数分析和因子分析方法。结果：所有的HiTOP-SR量表在癌症幸存者中显示出很强的同质性和可靠性。癌症幸存者在内化和躯体形态谱上表现出显著的升高，而当前的癌症与思维障碍领域以及去抑制和拮抗精神病理成分的额外升高有关。虽然因子负荷的大小有时在样本之间有所不同，但研究人员开发并支持了癌症和社区/精神病学样本的11因素模型。外部效度与理论一致的关联很强。结论：在癌症幸存者中，HiTOP-SR似乎是可靠的，并且在量化所经历的广泛的精神病理方面提供了实用价值。结果突出了HiTOP在提高肿瘤研究和心理肿瘤学临床实践方面的潜在适用性和实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psycho‐Oncology 医学-心理学

CiteScore

6.30

自引率

8.30%

发文量

220

审稿时长

3-8 weeks

期刊介绍： Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology. This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues. Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.